HETEROCYCLIC SYNTHESIS WITH NITRILES: SYNTHESIS OF SOME NOVEL PYRROLE, PYRROLO[1,2-a]QUINAZOLINE AND PYRROLO[1,2-a]TRIAZINE DERIVATIVES

Synthetic studies with 3‐Oxo‐N‐[4‐(3‐oxo‐ 3‐phenylpropionylamino)‐phenyl]‐3‐phenylpropionamide

“…The reaction of enaminones with active methylene reagents [15], amines [16], or hydrazines [17] represents one of the strategies for the preparation of 2‐1 H ‐pyridones, pyrroles, and pyridazines, respectively. Over the last two decades, we have been involved in a program aiming at the synthesis of functionally substituted heterocyclic compounds from cheap laboratory available starting materials to be evaluated as biodegradable agrochemicals [18–22]. As a part of this program, some bis‐pyridazine, bis‐pyridine, and other bis‐heterocyclic carboxamide derivatives were required for biological evaluation studies.…”

Heterosynthesis Using Nitriles: Novel Pyrrolo[2,3-<i>b</i>]pyridines

“…We have reported the synthesis of a variety of pyrrole, N-substituted pyrrole and fused-pyrrole derivatives of biological interest [9][10][11][12][13][14][15][16]. Recently some pyrrolo [2,3-b] pyridine derivatives were shown to be effective as inhibitors of tumor necrosis factor alpha [17].…”

“…Calcd for C 25 H 16 N 4 O 2 (404.42): C, 74.25; H, 3.99; N, 13.85. Found: C, 74.32; H, 3.95; N,13.65. 4-Amino-3-benzoyl-6-(furan-2-yl)-1-p-tolyl-1H-pyr rolo[2,3-b]pyridine-5-carbonitrile 6f: Brownish powder; yield 63% (2.63 g); mp 173˚C -175˚C.…”