Heterocyclic thioamide/phosphine mixed-ligand silver(I) complexes: Synthesis, molecular structures, DNA-binding properties and antibacterial activity

Silver(i) complexes bearing heterocyclic thioamide ligands with NH2 and CF3 substituents: effect of ligand group substitution on antibacterial and anticancer properties

“…77 From these data the EB-DNA quenching constants k q were calculated (eqn (S3) †) and found to be >10 10 M −1 s −1 (Table S12 †), providing an indication that quenching of EB-DNA fluorescence induced by the three complexes occurs via a static mechanism that entails the formation of a new conjugate, i.e., compound/CT-DNA. 78 The relatively low K SV constants of the complexes (compared to the K SV constants reported of recently reported analogous Ag(I) complexes 43 ) together with the observed moderate emission quenching of the EB-DNA solution suggest the low efficacy of the three complexes for intercalation into CT-DNA 58 (at least in the low concentration range with r < 0.15).…”

“…1 and Fig. S1-S5, † while selected geometrical parameters are summarized in Tables S2 and S3 † (the crystal structure of 3 was reported in one of our earlier works 58 and it is not discussed herein).…”

Multi-Spectroscopic and Molecular Simulation Approaches to Characterize the Intercalation Binding of 1-Naphthaleneacetic Acid With Calf Thymus DNA

“…When small molecules are inserted into DNA molecules, to keep space for small molecules, the distance between adjoining base pairs of DNA will increase and the DNA molecules will be lengthened, which will lead to an increase of DNA viscosity (Varna et al, 2018 ). While non-intercalation modes such as electrostatic binding and groove binding will not change the viscosity of DNA, because their action area is mainly outside the DNA molecules (Hong et al, 2018 ).…”

Crystal structure of tetra-μ-acetato-bis[(5-amino-2-methylsulfanyl-1,3,4-thiadiazole-κN 1)copper(II)]

“…Their diverse biological activity possibly arises from the presence of the NCS moiety in the molecule (Oruç et al, 2004). An interesting feature of the metal-ligand chemistry of these compounds is that the complexes can be either mononuclear (Tzeng et al, 2004;Varna et al, 2018;Qiu et al, 2014) or binuclear (Deckert et al, 2016;Ardan et al, 2017). A search of the Cambridge Structural Database (CSD Version 5.4, update of February 2019; Groom et al, 2016) revealed that although crystal structures have been reported for complexes of either 1,3,4-thiadiazole derivatives or OAc with a number of metal ions, including zinc, copper, nickel, manganese, cadmium, cobalt and palladium, no examples are known of mixed-ligand metal complexes containing both 1,3,4-thiadiazole derivatives and OAc.…”