Heterocyclic β-keto sulfide derivatives of carvacrol: Synthesis and copper (II) ion reducing capacity

Cocolas, Alexander H.; Parks, Eden L.; Ressler, Andrew; Havasi, Mia H.; Seeram, Navindra P.; Henry, Geneive E.

doi:10.1016/j.bmcl.2019.126636

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…Initial protection of the hydroxyl group of thymol was accomplished by its reaction with iodomethane in the presence of bicarbonate to afford methoxythymol (2) [54]. Subsequently, 4-acetylmethoxythymol (3) was obtained by acylation of 2 applying Friedel-Crafts conditions [55], followed by a condensation of 3 with the corresponding thiosemicarbazide under reflux and a catalytic amount of AcOH in ethanol to provide thiosemicarbazones 4a-b [56].…”

Section: Synthesismentioning

confidence: 99%

Synthesis, crystal structure and evaluation of anticancer activities of some novel heterocyclic compounds based on thymol

Laamari

Bimoussa

Fawzi

et al. 2023

Journal of Molecular Structure

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Section: Synthesismentioning

confidence: 99%

Synthesis, crystal structure and evaluation of anticancer activities of some novel heterocyclic compounds based on thymol

Laamari

Bimoussa

Fawzi

et al. 2023

Journal of Molecular Structure

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“…The presence of hydroxyl group (OH) in carvacrol is the major reason for its radical scavenging activity (superoxide radicals, nitric oxide, and hydrogen peroxide). Its weak acid character facilitates hydrogen atoms donation to unpaired electrons, making another radical stabilized by electron scattering produced at molecule resonance structure (Cocolas et al, 2019 ; Mir et al, 2020 ). Carvacrol protects against oxidative stress made by restraint stress damages the brain, liver, and kidney.…”

Section: Therapeutic Perspectivesmentioning

confidence: 99%

Therapeutic application of carvacrol: A comprehensive review

Imran¹,

Aslam

Alsagaby

et al. 2022

Food Science & Nutrition

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Carvacrol is a major natural constituent and is significantly present as an essential oil in aromatic plants and is well known for its numerous biological activities. Therapeutic properties of carvacrol have been demonstrated as anti‐oxidant, anticancer, diabetes prevention, cardioprotective, anti‐obesity, hepatoprotective and reproductive role, antiaging, antimicrobial, and immunomodulatory properties. The carvacrol biosynthesis has been mediated through mevalonate pathway. Carvacrol has the anticancer ability against malignant cells via decreasing the expressions of matrix metalloprotease 2 and 9, inducing apoptosis, enhancing the expression of pro‐apoptotic proteins, disrupting mitochondrial membrane, suppressing extracellular signal‐regulated kinase 1/2 mitogen‐activated protein kinase signal transduction, and also decreasing the phosphoinositide 3‐kinase/protein kinase B. It also decreased the concentrations of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase, and gamma‐glutamyl transpeptidase as well as also restored liver function, insulin level, and plasma glucose level. Carvacrol also has been found to exert antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Coagulase‐negative staphylococcus, Salmonella spp., Enterococcus sp. Shigella, and Escherichia coli. The current review article summarizes the health‐promoting perspectives of carvacrol through various pathways.

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Essential oils and capsaicin in the diet of Jersey cows at early lactation and their positive impact on anti-inflammatory, antioxidant and immunological responses

Leal,

Breancini

et al. 2024

Trop Anim Health Prod

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Heterocyclic β-keto sulfide derivatives of carvacrol: Synthesis and copper (II) ion reducing capacity

Cited by 7 publications

References 18 publications

Synthesis, crystal structure and evaluation of anticancer activities of some novel heterocyclic compounds based on thymol

Synthesis, crystal structure and evaluation of anticancer activities of some novel heterocyclic compounds based on thymol

Therapeutic application of carvacrol: A comprehensive review

Essential oils and capsaicin in the diet of Jersey cows at early lactation and their positive impact on anti-inflammatory, antioxidant and immunological responses

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