Heterodimerization of Calcium Sensing Receptors with Metabotropic Glutamate Receptors in Neurons

Gama, Lúcio; Wilt, Susan G.; Breitwieser, Gerda E.

doi:10.1074/jbc.m105662200

Cited by 143 publications

(97 citation statements)

References 68 publications

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“…Co-immunoprecipitation experiments revealed direct interactions of the CaSR with the mGluR1 , GABA B R 1 and GABA B R 2 in certain regions of bovine and rat brains [34,35]. These interactions have been shown to be determinative for both total cellular and cell surface expression of CaSR and the activation status of phospholipase C (PLC) [35].…”

Section: Receptor Dimerizationmentioning

confidence: 98%

The Calcium-Sensing Receptor as a Regulator of Cellular Fate in Normal and Pathological Conditions

Diez-Fraile¹,

Lammens²,

Benoit³

et al. 2013

Current Molecular Medicine

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Abstract:The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to sense small changes in circulating calcium concentration and to couple this information to intracellular signaling pathways that influence parathyroid hormone secretion. However, the presence of CaSR protein in tissues is not directly involved in regulating mineral ion homeostasis points to a role for the CaSR in other cellular functions including the control of cellular proliferation, differentiation and apoptosis. This position at the crossroads of cellular fate designates the CaSR as an interesting study subject is likely to be involved in a variety of previously unconsidered human pathologies, including cancer, atherosclerosis and Alzheimer's disease. Here, we will review the recent discoveries regarding the relevance of CaSR signaling in development and disease. Furthermore, we will discuss the rational for developing and using CaSR-based therapeutics.

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Section: Receptor Dimerizationmentioning

confidence: 98%

The Calcium-Sensing Receptor as a Regulator of Cellular Fate in Normal and Pathological Conditions

Diez-Fraile¹,

Lammens²,

Benoit³

et al. 2013

Current Molecular Medicine

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show abstract

“…Among all the available crystal structures of the mGluRs, studies on mGluR1 give concrete structural information about ligand-free as well as various ligand-bound forms of the receptor. Moreover, CaSR and mGluR1 share similar signaling pathways and can form heterodimers with one another either in vivo or in vitro (44). Thus, the crystal structures of mGluR1 were employed for modeling the CaSR ECD.…”

Section: Molecular Connectivity Among Predicted Calcium-binding Sitesmentioning

confidence: 99%

Identification of an l-Phenylalanine Binding Site Enhancing the Cooperative Responses of the Calcium-sensing Receptor to Calcium

Zhang

Huang

Jiang

et al. 2014

Journal of Biological Chemistry

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“…fected HEK293 cells in 96-well poly-L-lysine-coated plates were exposed to drugs as indicated in the figure legends, fixed and developed with anti-FLAG horseradish peroxidase antibody (1:1000 dilution, 3 h) as described (21). Untransfected HEK293 cells were used to estimate background.…”

Section: Enzyme-linked Immunoabsorption Assay (Elisa)-trans-mentioning

confidence: 99%

Rescue of Calcium-sensing Receptor Mutants by Allosteric Modulators Reveals a Conformational Checkpoint in Receptor Biogenesis

Huang

Breitwieser

2007

Journal of Biological Chemistry

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100

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Heterodimerization of Calcium Sensing Receptors with Metabotropic Glutamate Receptors in Neurons

Cited by 143 publications

References 68 publications

The Calcium-Sensing Receptor as a Regulator of Cellular Fate in Normal and Pathological Conditions

The Calcium-Sensing Receptor as a Regulator of Cellular Fate in Normal and Pathological Conditions

Identification of an l-Phenylalanine Binding Site Enhancing the Cooperative Responses of the Calcium-sensing Receptor to Calcium

Rescue of Calcium-sensing Receptor Mutants by Allosteric Modulators Reveals a Conformational Checkpoint in Receptor Biogenesis

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