Heterogeneic antigens of pasteurella pestis and vibrio cholerae similar to human and animal tissue antigens

Zhukov-Verzhnikov, N. N.; Адамов, А. К.; Anisimov, P. I.; Bochko, G. M.; Podoplelov, I. I.; Гончарова, Н. С.; Karaseva, Z. N.; Shchurkina, I. I.

doi:10.1007/bf00809833

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“…Taken together with the production by Y. pestis of some heterogeneous substances serologically related to above-mentioned antigens, and inability to synthesize other species-specific antigens (i.e. F1, Pla, Ymt), this can, probably, provide mimicry of Y. pestis to some human tissues and blood cells (Zhukov-Verezhnikov et al, 1972) resulting in the absence of immune response and inflammation in the site of infection at the early stage of the disease (Domaradskii, 1998). The resistant Y. pestis bacteria were more round than those grown in routine conditions and demonstrated a significantly thinner envelope with alteration of the production of capsular substance and LPS architecture.…”

Section: Polysaccharide Modifications In Supplemented Growth Mediamentioning

confidence: 99%

Antigenic and phenotypic modifications of Yersinia pestis under calcium and glucose concentrations simulating the mammalian bloodstream environment

Feodorova

Голова

2005

Journal of Medical Microbiology

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To study the possible mechanism of extracellular resistance to phagocytes developed by Yersinia pestis in the early stage of plague infection, the behaviour of two Y. pestis strains, the vaccine EV-76 and fully virulent 231 (LD 50 , 10 c.f.u.), was studied in-depth after cultivation in vitro at the host temperature in conditions simulating the bloodstream environment of mammals. For this, two standard basal media supplemented with calcium and glucose in appropriate concentrations were employed: Hottinger broth, routinely used for growth of Y. pestis in vitro, and RPMI 1640, simulating human extracellular fluid. Although both media permitted Y. pestis to achieve the resistant state, RPMI enabled significantly higher bacterial proliferation and increased modifications in the production of the principal surface antigens that affect the relevant phenotype characteristics. In general, our results indicate that the Y. pestis bacteria in the resistant state do not produce speciesspecific antigens, i.e. fraction 1 or F1, 'murine' toxin or Ymt, plasminogen activator (Pla) and any surface-specific polysaccharides, resulting in unmasking of the cross-reactive epitopes of lipid A in reduced Y. pestis lipopolysaccharide. This may produce mimicry by Y. pestis of some human tissue and blood cell components, with no immune response and inflammation at the site of infection at the early stage, which enables Y. pestis to survive, extensively multiply and spread into the circulation.

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Section: Polysaccharide Modifications In Supplemented Growth Mediamentioning

confidence: 99%

Antigenic and phenotypic modifications of Yersinia pestis under calcium and glucose concentrations simulating the mammalian bloodstream environment

Feodorova

Голова

2005

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

Heterogeneic antigens of pasteurella pestis and vibrio cholerae similar to human and animal tissue antigens

Cited by 1 publication

References 1 publication

Antigenic and phenotypic modifications of Yersinia pestis under calcium and glucose concentrations simulating the mammalian bloodstream environment

Antigenic and phenotypic modifications of Yersinia pestis under calcium and glucose concentrations simulating the mammalian bloodstream environment

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