Heterogeneity and plasticity of epidermal stem cells

Schepeler, Troels; Page, Mahalia E.; Jensen, Kim B.

doi:10.1242/dev.104588

Cited by 105 publications

(100 citation statements)

References 116 publications

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“…Some are similar to the HSC in maintaining tissues with a high turnover such as the intestinal and skin (reviewed in Barker, 2014;Hsu et al, 2014;Schepeler et al, 2014). While in other tissues such as skeletal muscle, stem cells known as the satellite cells minimally contribute to myofiber maintenance during homeostasis but serve an important role in regeneration after injury (reviewed in Brack and Rando, 2012).…”

Section: Mesenchymal Cells In Other Adult Stem Cell Nichesmentioning

confidence: 99%

Mesenchymal Cell Contributions to the Stem Cell Niche

2015

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Mesenchymal stromal cells (MSCs) are heterogeneous and primitive cells discovered first in the bone marrow (BM). They have putative roles in maintaining tissue homeostasis and are increasingly recognized as components of stem cell niches, which are best defined in the blood. The absence of in vivo MSC markers has limited our ability to track their behavior in vivo and draw comparisons with in vitro observations. Here we review the historical background of BM-MSCs, advances made in their prospective isolation, their developmental origin and contribution to maintaining subsets of hematopoietic cells, and how mesenchymal cells contribute to other stem cell niches.

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Section: Mesenchymal Cells In Other Adult Stem Cell Nichesmentioning

confidence: 99%

Mesenchymal Cell Contributions to the Stem Cell Niche

2015

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“…Each stem cell compartment is defined by distinct protein expression and gene promoter activity (see key); cells with multiple colors express multiple markers. Reprinted from Schepeler et al [27]. …”

Section: The Entry Of Naïve Sebaceous Glands Into the Acne Cycle: Thementioning

confidence: 99%

Strategic Targets in Acne: The Comedone Switch in Question

Saurat¹

2015

Dermatology

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The sequence of events and mechanisms leading to the development of the primary acne lesion, the comedone, is revisited. Recent knowledge obtained both from lineage tracing experiments in the mouse and the pilosebaceous response to xenobiotics in humans provides robust models for further understanding key biological events at the cellular roots of comedogenesis. The focus is set on the LRIG1+ sebaceous stem cells in the isthmus of the pilosebaceous duct. The master switch that transforms a normally functioning sebaceous gland into a microcomedone and the hierarchy of factors involved in this process are reviewed. The key strategic target in acne care appears to be the naïve pilosebaceous follicle that is not involved yet in the acne cycle. The prevention of the comedone switch implies that the key switching factors are adequately controlled in the long term.

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“…7,8 Consequently, stem cells that do not ordinarily encounter one another during homeostasis, such as those of the HF bulge and the basal layer of the IFE, are suddenly brought into contact when they converge at the wounded area. 8 Although multiple reports have documented the overall persistence of different HF stem cell-derived sub-populations following wound healing, [9][10][11][12][13][14][15][16] few have quantitated the specific ability of these cells to populate the permanent, basal layer of the regenerating epithelium over time.…”

Section: Introductionmentioning

confidence: 99%

Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration

2015

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Upon wounding, multiple stem cell populations in the hair follicle (HF) and interfollicular epidermis (IFE) converge at the site of injury. Although these cells can contribute permanently to the regenerating epithelium, it remains unclear whether these contributions vary among cells originating from diverse compartments in the skin. By comparing the fates of several keratinocyte lineages, we observed here an initial decrease in both HF-and IFE-derived cells within the transient acanthotic layers of the regenerating epithelium. At the same time, the relative abundance of early-arriving IFE-derived cells specifically in the wound basal layer declined as later-arriving HF-derived cells entered the site of injury. Although laggard bulge-derived cells were typically constrained at the regenerative periphery, these cells persisted in the wound basal layer. Finally, suppressing Notch enabled IFE-derived cells to out-compete HF-derived cells. Taken together, these findings indicate that IFE-, HF-and bulge-derived cells make distinct contributions to regeneration over time. Furthermore, we speculate that extrinsic, non-genetic factors such as spatial constraint, distance from the wound, and basal versus suprabasal position may largely determine whether a cell ultimately persists.

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Heterogeneity and plasticity of epidermal stem cells

Cited by 105 publications

References 116 publications

Mesenchymal Cell Contributions to the Stem Cell Niche

Mesenchymal Cell Contributions to the Stem Cell Niche

Strategic Targets in Acne: The Comedone Switch in Question

Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration

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