Heterogeneity and symptom structure of schizophrenia

Picardi, Angelo; Viroli, Cinzia; Tarsitani, Lorenzo; Miglio, Rossella; Girolamo, Giovanni de; Dell'Acqua, Giuseppe; Biondi, Massimo

doi:10.1016/j.psychres.2011.12.051

Cited by 65 publications

(41 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, serum sampling does not reflect brain levels and, in fact, NCS-1 levels in leukocytes are actually decreased in schizophrenic patients (Torres et al 2009). However, future clinical trials in patients with schizophrenia or bipolar disorder may benefit from prior determination of a significant decrease in gamma-band activity, which may also help address the heterogeneity of schizophrenia and facilitate the process of identifying more homogeneous groups within the syndrome (Picardi et al 2012). It is to those patients that pharmacological targeting to increase gamma-band activity may be of benefit.…”

Section: Discussionmentioning

confidence: 99%

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

D’Onofrio

Kezunovic

Hyde

et al. 2015

Journal of Neurophysiology

View full text Add to dashboard Cite

D'Onofrio S, Kezunovic N, Hyde JR, Luster B, Messias E, Urbano FJ, Garcia-Rill E. Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder. J Neurophysiol 113: 709 -719, 2015. First published November 5, 2014 doi:10.1152/jn.00828.2014.-Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1. We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gammaband activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1. Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

D’Onofrio

Kezunovic

Hyde

et al. 2015

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

“…CD, which is classified as a symptom of formal thought disorder, usually refers to irrelevant, digressive, or confused oral proclamations [39]. The patients with schizophrenia were better educated than those with MAP in this study; therefore, we could be sure that the differences in CD were not attributed to educational levels.…”

Section: Discussionmentioning

confidence: 80%

Differences in Clinical Features of Methamphetamine Users with Persistent Psychosis and Patients with Schizophrenia

Wang

Lin²,

Chen³

et al. 2016

Psychopathology

View full text Add to dashboard Cite

Background: Methamphetamine exerts neurotoxic effects and elicits psychotic symptoms. This study attempted to compare clinical differences between methamphetamine users with persistent psychosis (MAP) and patients with schizophrenia. In addition, we examined the discrimination validity by using symptom clusters to differentiate between MAP and schizophrenia. Methods: We enrolled 53 MAP patients and 53 patients with schizophrenia. The psychopathology of participants was assessed using the Chinese version of the Diagnostic Interview for Genetic Studies and the 18-item Brief Psychiatric Rating Scale. Logistic regression was used to examine the predicted probability scores of different symptom combinations on discriminating between MAP and schizophrenia. The receiver operating characteristic (ROC) analyses and area under the curve (AUC) were further applied to examine the discrimination validity of the predicted probability scores on differentiating between MAP and schizophrenia. Results: We found that MAP and schizophrenia demonstrated similar patterns of delusions. Compared to patients with schizophrenia, MAP experienced significantly higher proportions of visual hallucinations and of somatic or tactile hallucinations. However, MAP exhibited significantly lower severity in conceptual disorganization, mannerism/posturing, blunted affect, emotional withdrawal, and motor retardation compared to patients with schizophrenia. The ROC analysis showed that a predicted probability score combining the aforementioned 7 items of symptoms could significantly differentiate between MAP and schizophrenia (AUC = 0.77). Conclusion: Findings in the current study suggest that nuanced differences might exist in the clinical presentation of secondary psychosis (MAP) and primary psychosis (schizophrenia). Combining the symptoms as a whole may help with differential diagnosis for MAP and schizophrenia.

show abstract

“…Firstrank symptoms and self-disturbances might then still serve as a useful clinical tool [46] yet without bearing the burden of being schizophrenia's specific core. Beyond the debate on what qualifies as an adequately specific schizophrenic core disturbance, the view of schizophrenia as a unitary nosological category as such is nowadays increasingly called into question: e.g., it has so far not been possible to identify a common factor structure of schizophrenia symptoms [47] . Furthermore, there is a rising awareness of important communalities between schizophrenia and other conditions like bipolar disorder [48] .…”

Section: Demarcation From Other Mental Illnessesmentioning

confidence: 99%

Schizophrenia, Self, and Person: Eugen Bleuler and Arthur Kronfeld on a Conceptual Alliance

Maatz

Hoff

2017

Psychopathology

View full text Add to dashboard Cite

The conceptual history of schizophrenia is marked by considerable dissent about its nosological status, and the question of whether it represents a distinct disease entity remains hotly debated. Another recurring feature in the conceptual history of schizophrenia is the reference to concepts of self and person. This paper brings in connection these two debates by interrogating the nosological function of “self” and “person” by means of a fictitious dialogue between Eugen Bleuler, the inventor of schizophrenia, and his contemporary Arthur Kronfeld. Introducing their respective accounts of schizophrenia with a special focus on how concepts of self and person figure therein, our analysis suggests that these concepts are primarily employed in an attempt to guarantee the nosological unity of schizophrenia: mediated by the concept of a core disturbance, alterations of the self or the person thus become the essential core of schizophrenia. Yet, rather than providing an easy solution to the nosological problem of the unity of schizophrenia, the concepts of self and person and their assumed disturbances are themselves fraught with debates about unity. We discuss these conceptual challenges in light of present-day nosological debates and the currently abounding research on the self.

show abstract

Heterogeneity and symptom structure of schizophrenia

Cited by 65 publications

References 41 publications

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

Differences in Clinical Features of Methamphetamine Users with Persistent Psychosis and Patients with Schizophrenia

Schizophrenia, Self, and Person: Eugen Bleuler and Arthur Kronfeld on a Conceptual Alliance

Contact Info

Product

Resources

About