Heterogeneity in the Development of Proactive and Reactive Aggression in Childhood: Common and Specific Genetic - Environmental Factors

Paquin, Stéphane; Lacourse, Éric; Brendgen, Mara; Vitaro, Frank; Tremblay, Richard E.; Dionne, Ginette; Boivin, Michel

doi:10.31219/osf.io/xku9j

Cited by 7 publications

(8 citation statements)

References 38 publications

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“…Families were initially enrolled in the QNTS if the mother was fluent in French or English, and the twins had no major medical complications at birth. Zygosity was initially assessed via questionnaire and confirmed with DNA tests on a subsample of n = 123 same‐sex pairs (96% correspondence; Forget‐Dubois et al, ) Participant twins of QNTS did not differ from same‐age singleton children from a representative cohort from Québec (Paquin et al, ). In this study, we considered teacher ratings of the twins' impulsive‐aggression from age 6 to 12 years and subsequent self‐reported lifetime suicidality by age 20 years.…”

Section: Methodsmentioning

confidence: 99%

“…These findings suggest that individual variability in baseline level and developmental change (i.e., decreasing vs. stability/increasing) of impulsive‐aggression may play a different role in subsequent suicidality. In line with this, genetically informed studies suggest that baseline level and developmental course of aggressive behaviors in childhood may have distinct genetic etiology (Lacourse et al, ; Paquin et al, ; Pingault, Viding, et al, ).…”

Section: Introductionmentioning

confidence: 91%

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Contribution of genes and environment to the longitudinal association between childhood impulsive‐aggression and suicidality in adolescence

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Geoffroy

Turecki

et al. 2019

Child Psychology Psychiatry

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Background: Population-based and family studies showed that impulsive-aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive-aggression and serious suicidal ideation/attempt in young adulthood. Methods: N = 862 twins (435 families) from the Quebec Newborn Twin Study were followed up from birth to 20 years. Repeated measures of teacher-assessed impulsive-aggression were modeled using a genetically informed latent growth model including intercept and slope parameters reflecting individual differences in the baseline level (age 6 years) and in the change (increase/decrease) of impulsiveaggression during childhood (6 to 12 years), respectively. Lifetime suicidality (serious suicidal ideation/attempt) was self-reported at 20 years. Associations of impulsive-aggression intercept and slope with suicidality were decomposed into additive genetic (A) and unique environmental (E) components. Results: Additive genetic factors accounted for an important part of individual differences in impulsive-aggression intercept (A = 90%, E = 10%) and slope (A = 65%, E = 35%). Genetic (50%) and unique environmental (50%) factors equally contributed to suicidality. We found that 38% of the genetic factors accounting for suicidality were shared with those underlying impulsive-aggression slope, whereas 40% of the environmental factors accounting for suicidality were shared with those associated with impulsive-aggression intercept. The genetic correlation between impulsive-aggression slope and suicidality was 0.60, p = .027. Conclusions: Genetic and unique environmental factors underlying suicidality significantly overlap with those underlying childhood impulsive-aggression. Future studies should identify putative genetic and environmental factors to inform prevention. a Mean (SD).Impulsive-aggression is a main behavioral risk factor for suicide, but it is unknown to what extent genetic and environmental factors contribute to this association.Genetic and environmental factors underlying adolescent suicidality significantly overlap with genetic and environmental factors underlying childhood impulsive-aggression.The genetic and environmental factors underlying baseline level of impulsive-aggression (6 years) and those associated with changes in impulsive-aggression during childhood (6 to 12 years) differently contributed to suicidality.Future studies should identify putative genetic and environmental factors accounting for the association between impulsive-aggression and suicidality using a developmental perspective.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Contribution of genes and environment to the longitudinal association between childhood impulsive‐aggression and suicidality in adolescence

Orri

Geoffroy

Turecki

et al. 2019

Child Psychology Psychiatry

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“…There is ongoing debate about the utility of the distinction between proactive and reactive subtypes of aggression broadly, underscored by the challenges inherent in correct identification (Girard, Tremblay, Nagin, & Cote, 2019). However, there is also an extensive literature repeatedly demonstrating the discriminant validity and distinct antecedents and consequences of these two subtypes (Kempes, Matthys, De Vries, & Van Engeland, 2005;Paquin et al, 2017;Poulin & Boivin, 2000;Vitaro, Brendgen, & Tremblay, 2002), and indirect and direct forms of both reactive and proactive RAgg can reliably be measured (Voulgaridou & Kokkinos, 2018). Previous research suggests reactive and proactive RAgg subtypes have unique correlates (Marsee et al, 2014;Marsee & Frick, 2007).…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Relational Aggression and Narcissistic Traits: How Youth Personality Pathology Informs Aggressive Behavior

Reardon

Herzhoff

Smack

et al. 2020

Journal of Personality Disorders

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Low agreeableness features centrally in personality profiles of Cluster B personality disorder (PD) diagnoses, and it has been associated with relational aggression (RAgg; intentionally damaging others' social relationships). Researchers have hypothesized that RAgg may be a potential developmental precursor for Cluster B PDs. However, a dimensional approach to personality dysfunction is preferable to the categorical system found in the current diagnostic manual. To build a bridge between two disjointed literatures (categorical PDs and RAgg), the aim of this project is to detail how RAgg in youth is situated in the trait space represented by disagreeableness in a dimensional model of personality pathology. Caregivers of 911 youth (ages 6-18) reported on youth's RAgg and disagreeableness. We found that RAgg was most strongly related to three facets: Narcissistic traits, Hyperexpressive traits, and Dominance-Egocentrism traits. Overall, these findings provide support for RAgg as an early manifestation of personality pathology, particularly for narcissistic traits.

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“…We have documented the genetic and environmental contributions to a variety of behavioral, educational, and health outcomes, as well as their associations, including different forms and functions of aggressive behaviors, such as reactive versus proactive versus social aggression (Brendgen et al, 2005(Brendgen et al, , 2006Paquin et al, 2017), early physical aggression and language (Dionne et al, 2003), early numeracy and later achievement in mathematics (Garon-Carrier et al, 2017), early sleep patterns and language development (Dionne et al, 2011;Touchette et al, 2013), attention-deficit/ hyperactivity and reading (Plourde et al, 2015(Plourde et al, , 2017, gambling and substance use (Vitaro et al, 2014(Vitaro et al, , 2018, callous-unemotional traits and fear recognition (Petitclerc et al, 2019), as well as more basic endophenotypes such as cortisol (Ouellet-Morin et al, 2016) and response inhibition (Schachar et al, 2011). We also showed that the stability of various social behaviors, such as disregard for rules (a central component of early opposition), physical aggression, callous-unemotional traits, and shyness, was more highly, and often quite substantially associated with genetic factors than their episodic manifestations (Henry, Dionne, Viding, Petitclerc et al, 2018;Lacourse et al, 2014;Morneau-Vaillancourt et al, 2019;Petitclerc et al, 2011).…”

Section: Scientific Contributionsmentioning

confidence: 99%

The Quebec Newborn Twin Study at 21

et al. 2019

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This paper is a revised and updated edition of a previous description of the Quebec Newborn Twin Study (QNTS), an ongoing prospective longitudinal follow-up of a birth cohort of twins born between 1995 and 1998 in the greater Montreal area, Québec, Canada. The goal of QNTS is to document individual differences in the cognitive, behavioral, and social-emotional aspects of developmental health across childhood, their early genetic and environmental determinants, as well as their putative role in later social-emotional adjustment, school, health, and occupational outcomes. A total of 662 families of twins were initially assessed when the twins were aged 6 months. These twins and their family were then followed regularly. QNTS now has 16 waves of data collected or planned, including 5 in preschool. Over the last 24 years, a broad range of physiological, cognitive, behavioral, school, and health phenotypes were documented longitudinally through multi-informant and multimethod measurements. QNTS also entails extended and detailed multilevel assessments of proximal (e.g., parenting behaviors, peer relationships) and distal (e.g., family income) features of the child’s environment. QNTS children and a subset of their parents have been genotyped, allowing for the computation of a variety of polygenic scores. This detailed longitudinal information makes QNTS uniquely suited for the study of the role of the early years and gene–environment transactions in development.

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Heterogeneity in the Development of Proactive and Reactive Aggression in Childhood: Common and Specific Genetic - Environmental Factors

Abstract: Background

Cited by 7 publications

References 38 publications

Contribution of genes and environment to the longitudinal association between childhood impulsive‐aggression and suicidality in adolescence

Contribution of genes and environment to the longitudinal association between childhood impulsive‐aggression and suicidality in adolescence

Relational Aggression and Narcissistic Traits: How Youth Personality Pathology Informs Aggressive Behavior

The Quebec Newborn Twin Study at 21

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