Formation overpressure is an important controlling factor for the formation of high-yield oil reservoirs in the shale series of the Permian Fengcheng Formation in the west and south of Mahu Sag, the Junggar Basin. Hydrocarbon-generating pressurization (HGP) is an important cause of overpressure in the shale series of Fengcheng Formation, but the evidence for this viewpoint is insufficient. There is still no systematic study on the quantitative calculation and distribution characteristics of HGP in the Fengcheng Formation shale series. The control effect of HGP on the formation of high-pressure and high-yield reservoirs is still unclear. Therefore, by using the data of mudstone logging and measured formation pressure, the causes of overpressure in the Fengcheng Formation shale series are clarified. The predicted organic matter abundance, the predicted maturity and thickness of source rocks, and the statistical ratios of mudstone thickness to formation thickness in each section of Fengcheng Formation are used for HGP of shale series. Combined with the physical characteristics of reservoir rocks and the geochemical characteristics of oil, the control effect of HGP on the formation of high-pressure and high-yield reservoirs is analyzed. The results indicate the following: (1) The organic matter abundance and the thickness of source rocks predicted by the logging data gradually decrease from the eastern lake basin area to the western slope area. (2) The HGP of shale series in Fengcheng Formation is related to the hydrocarbon generation capacity and the overpressure preservation conditions of the source rocks. The HGP can be quantitatively predicted by comprehensively using the organic matter abundance, the maturity, the thickness of source rocks, and the ratios of mudstone thickness to formation thickness. (3) The HGP in the Fengcheng Formation shale series also gradually decreases in distribution characteristic from the eastern lake basin area to the western slope area. (4) The oil accumulation mode of the Fengcheng Formation shale series is that, with the drive of overpressure, the oil migrates slightly within the layer, and finally accumulates to form the oil reservoir. The research results are helpful to understand the distribution characteristics of HGP and the formation mechanism of high-pressure and high-yield reservoirs in the shale series of Fengcheng Formation in the west and south of Mahu Sag, and are of great significance to guide the exploration and development of shale oil and tight oil.