Heterogeneity of Crow's Feet Line Patterns in Clinical Trial Subjects

Kane, Michael; Cox, Sue Ellen; Jones, Derek; Lei, Xiaofang; Gallagher, Conor J.

doi:10.1097/dss.0000000000000336

Cited by 35 publications

(37 citation statements)

References 15 publications

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“…As described in the physician prescribing information, 2 injection patterns were available for treating CFL, depending on investigators' assessment and varying pattern/location of the CFL. 22 Bimatoprost was to be applied nightly to the skin of the upper eyelid margin at the base of the eyelashes bilaterally by each subject in accordance with the instructions provided in the package insert, for the duration of the study. 20…”

Section: Study Treatmentsmentioning

confidence: 99%

A Comprehensive Approach to Multimodal Facial Aesthetic Treatment

Narurkar

Cohen

Dayan

et al. 2016

Dermatologic Surgery

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Section: Study Treatmentsmentioning

confidence: 99%

A Comprehensive Approach to Multimodal Facial Aesthetic Treatment

Narurkar

Cohen

Dayan

et al. 2016

Dermatologic Surgery

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“…In these trials, improvement in CFL severity with onabotulinumtoxinA treatment was evaluated using the Facial Wrinkle Scale (FWS; Allergan plc, Dublin, Ireland) [ 2 , 3 ]. However, it has been noted that Asian facial skin has increased dermal thickness, collagen content, and melanin [ 4 – 6 ], and assessment of CFL morphology in Asian subjects has shown slightly different CFL pattern prevalence compared with predominantly Caucasian subjects [ 5 , 6 ]. For these reasons, the FWS with Asian Photonumeric Guide (FWS-A) was designed to provide clinicians with a standardized, static method for assessing the severity of facial lines in Asian subjects.…”

Section: Introductionmentioning

confidence: 99%

OnabotulinumtoxinA (Botox) in the Treatment of Crow’s Feet Lines in Japanese Subjects

et al. 2017

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BackgroundThis study evaluated the safety and efficacy of onabotulinumtoxinA in Japanese subjects with crow’s feet lines (CFL).MethodsThis phase 3, multicenter, double-blind, randomized study included 2 treatment periods: 6-month placebo-controlled period followed by a 7-month open-label period. In period 1, subjects with moderate to severe CFL received onabotulinumtoxinA 24 U (n = 104) or 12 U (n = 99), or placebo (n = 97). In period 2, placebo subjects switched to onabotulinumtoxinA 24 U or 12 U (double-blind dose). Up to 5 total treatments were permitted for subjects meeting re-treatment criteria. The primary efficacy measure was the proportion of investigator-assessed responders (achieving CFL severity of none or mild at maximum smile using the Facial Wrinkle Scale with Asian Photonumeric Guide [FWS-A] at day 30 of treatment 1). Additional endpoints included other responders (achieving at least 1-grade improvement at maximum smile and at rest using the FWS-A at day 30), responders at other time points, duration of effect, subject-reported outcomes, and safety.ResultsAll efficacy endpoints were met. At day 30, the proportion of subjects achieving none or mild severity at maximum smile was significantly greater (P < 0.001) in the onabotulinumtoxinA 24 and 12 U groups (68.3 and 56.6%, respectively) compared with the placebo group (8.2%). Efficacy results were consistent over repeated treatments, and subjects’ self-assessed outcomes were similar to investigator-assessed results.ConclusionsTreatment with onabotulinumtoxinA 24 and 12 U improved the appearance of CFL in Japanese subjects and was well tolerated, with no new safety findings.Level of Evidence IThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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“…Consideramos oportuno reconhecer que características como gênero e etnia influenciam no padrão de distribuição e severidade das rítides faciais (KANE, 2003); (KANE et al, 2015). A chave para o sucesso do tratamento é sempre uma análise individualizada do paciente de acordo com suas necessidades.…”

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Comparação entre a dose e a distribuição de pontos de aplicação de toxina botulínica tipo A na eficácia para o tratamento de rítides glabelares. Ensaio clínico randomizado duplo cego

Santos

Souza

Dias

et al. 2020

BJD

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Botulinum toxin has been used safely and effectively for the treatment of glabellar rhytids. However, clinical practice has been varied, leaving doubts about the optimal dose and the number of injection points. The objective of this work is, therefore, to evaluate the effect of concentration and application points of botulinum toxin in the treatment of glabellar rhytids. Forty volunteers were randomly divided into 4 groups: G1: one injection point in procerus muscle (5U) and one injection point in corrugator muscle (5U); G2: one injection point in procerus muscle (5U) and two injection points in corrugator muscle (2.5U per point); G3: one injection point in procerus muscle (7U) and one injection point corrugator muscle (7U per point); G4: one injection point in procerus muscle (7U) and two injection points in corrugator muscle (5U per point). Participants were assessed at baseline and weeks 2, 8, 16 by the Wrinkle Scale Facial method. The results of this study suggest that at the dosages studied, 21U applied at one point per muscle is an effective dose for the treatment of the glabellar region, lasting 4 months.

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Heterogeneity of Crow's Feet Line Patterns in Clinical Trial Subjects

Abstract: Baseline CFL severity, age, and gender may predict fan pattern. Patterns may progress with age from central to lower fan or full fan. Pattern heterogeneity of CFLs suggests that tailored treatment may be warranted.

Cited by 35 publications

References 15 publications

A Comprehensive Approach to Multimodal Facial Aesthetic Treatment

A Comprehensive Approach to Multimodal Facial Aesthetic Treatment

OnabotulinumtoxinA (Botox) in the Treatment of Crow’s Feet Lines in Japanese Subjects

Comparação entre a dose e a distribuição de pontos de aplicação de toxina botulínica tipo A na eficácia para o tratamento de rítides glabelares. Ensaio clínico randomizado duplo cego

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