2013
DOI: 10.1111/liv.12100
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Heterogeneity of fibrosis patterns in non‐alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways

Abstract: Differing associations with portal and centrilobular fibrosis in children and atypical fibrosis patterns in adults suggest that multiple fibrogenic pathways exist in NAFLD. This has implications for therapy and understanding pathogenesis.

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Cited by 47 publications
(43 citation statements)
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“…The individual aetiology of liver disease may further affect the response of isolated phHSC to VD treatment. For example, recent findings of Skoien et al 28 suggest multiple fibrogenic mechanisms. This may be also indicated by our preliminary studies, which showed that phHSC isolated from patients with viral hepatitis did not respond or responded only marginally to VD treatment (data not shown).…”
Section: Discussionmentioning
confidence: 99%
“…The individual aetiology of liver disease may further affect the response of isolated phHSC to VD treatment. For example, recent findings of Skoien et al 28 suggest multiple fibrogenic mechanisms. This may be also indicated by our preliminary studies, which showed that phHSC isolated from patients with viral hepatitis did not respond or responded only marginally to VD treatment (data not shown).…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that the activation of HPCs is associated with fibrosis progression27 in chronic viral hepatitis9 12 18 28 and NAFLD 10 13 29. Namely, liver injury due to viral infection or oxidative stress causes hepatic stellate cell activation as well as HPC expansion for liver regeneration.…”
Section: Discussionmentioning
confidence: 99%
“…Fibrosis in adults with NASH is classically peri-cellular and forms a dense, reticular network of “chicken wire” fibrosis affecting the lobular liver parenchyma [82]. In paediatric NASH, however, the phenotype is quite different with pure portal fibrosis representing the typical lesion, although the adult phenotype and a mixed pattern can also occur [8385]. The reasons behind this heterogeneity of fibrosis patterns are unclear but potentially multiple fibrogenic pathways exist in NASH, with progression to an individual phenotype driven by genetic predispositions and complex inter-cellular interactions [85].…”
Section: Progressive Nash: From Inflammation To Fibrosismentioning
confidence: 99%
“…Observational studies have demonstrated that the presence of portal fibrosis is typically associated with a chronic, portal inflammatory infiltrate [87], as well as a peri-portal DR and expansion of the HPC compartment [88]. More recently an association between portal fibrosis and the DR and increased HPC numbers has also been demonstrated in paediatric NASH [85], suggesting that portal-based factors may be more important to disease progression than traditional lobular factors, such as hepatocyte steatosis and inflammation.…”
Section: Progressive Nash: From Inflammation To Fibrosismentioning
confidence: 99%
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