Heterogeneity of platelet responsiveness to anti‐CD36 in plasma associated with adverse transfusion reactions

Abstract

Plasma containing anti-CD36, implicated in the development of NHTRs, exhibited a platelet-activating capability. Additionally, platelets from healthy human subjects exhibited a considerable degree of heterogeneity in their responsiveness to this plasma. The heterogeneity of these responses may determine the occurrence of anti-CD36-related NHTRs.

Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment

“…These CD36 antibodies exhibited PLT‐activating capability mediated though FcγRIIa, and, interestingly, PLTs from healthy human subjects exhibited a considerable degree of heterogeneity in their responsiveness to this plasma. The PLT surface expression levels of CD36 and FcγRIIa and their degree of binding to these antibodies were apparently associated with the profound differences in PLT responsiveness to this plasma (Wakamoto et al , ).…”

Life‐threatening adverse reaction followed by thrombocytopenia after passive transfusion of fresh frozen plasma containing anti‐CD36 (Naka) isoantibody

“…The other suggested the involvement of a mediator, such as RANTES released from activated PLTs 19 . It should be stressed that we found that S.S. plasma could induce the aggregation of PLTs derived from some (but not all) healthy adults and release of RANTES 20 . Thus, we speculated that the patient's PLT could also be activated by the S.S. plasma.…”

“…19 It should be stressed that we found that S.S. plasma could induce the aggregation of PLTs derived from some (but not all) healthy adults and release of RANTES. 20 Thus, we speculated that the patient's PLT could also be activated by the S.S. plasma. In other words, the serious adverse effects including hypotension might be caused by the aggregation of PLTs in the circulation induced by the anti-CD36 isoantibody in the S.S. plasma, resulting in the release of various mediators.…”

Simultaneous five cell‐lineage flow cytometric analysis system for detection of leucocyte antibodies

“…(2003) reported that TRALI‐related antibodies could activate monocytes as well and induce increased cytoplasmic expression of interleukin‐1, tumour necrosis factor‐α and tissue factor. In addition, platelet antibodies and associated platelet activation have also been described in nonhaemolytic transfusion reactions (Taylor et al ., 2000; Wakamoto et al ., 2005). Therefore, it is important to clarify whether antibodies in a blood product can bind on blood cells of a patient when transfused.…”