Heterogeneity of teta-activity and its sources in Parkinson's disease

Abstract

The risk of appearance of non-motor symptoms including cognitive dysfunctions is increased while Parkinson's disease (PD) progression. A lot of EEG-studies have shown that the degree of cognitive impairments correlates with increasing of θ-band spectral power. The aim of this research was to investigate the cause of such phenomenon. The resting state EEGs of 30 patients with PD and 30 healthy volunteers 45-65 years old were analyzed. We have established that the increasing of θ power has heterogenic nature. First reason is greater activity of existing θ-generators, mainly in posterior cingulate cortex. The other reason is the decreasing of the dominant resting state rhythm's frequency, which can affect the values of spectral power of θ-band.