Heterogeneity of the risk of suicidal behavior in bipolar‐spectrum disorders

Abstract

Suicidal behavior is distributed unevenly in families of probands with BD, aggregating in a subset of families. Our results also suggest that partially overlapping sets of genetic factors may underlie BD and suicide.

Genetic risk of suicidal behavior in bipolar spectrum disorder: analysis of 737 pedigrees

“…The procedures of the assessment of suicidal behavior are detailed in Cavazzoni et al. and included the use of SADS‐L for collecting information on lifetime occurrence of suicidal behavior. Briefly, suicide attempt was defined as an intentional self‐inflicted injury with self‐destructive intent.…”

“…In a previous study, we investigated the relationship between the genetic vulnerability to suicide and the genetic predisposition to MAD, and BD in particular, in a consecutive sample of 78 families . The distribution of the risk of suicidal behavior was heterogeneous, with completed suicides and suicide attempts aggregating in two subgroups of families (high and intermediate risk).…”

“…The large sample included in this study should ensure an accurate estimate of the prevalence parameters. Whereas our previous study was in a sample of families with lithium‐responsive probands , here we analyzed a more heterogeneous group of families and collected information on the lithium treatment response.…”

Selected papers from the Sixth International Conference on Bipolar Disorder: from epidemiology to endophenotypes to advances in therapeutics

“…[Notably, prior studies suggest that suicidal behavior may be more prevalent in first-degree relatives of bipolar than non-bipolar probands (9)]. In this special issue, Cavazzoni et al (10) extend prior findings in this area, noting not only that firstdegree relatives of individuals with BD have an elevated risk for suicide attempts, but moreover, that family histories of BD may be more common in people who have made a suicide attempt.…”

Avrupada ekonomik kriz ve özkıyım istatistikleri

“…Mood disorders are found in 80-85% (39)(40)(41) and schizophrenia in 9-13% of patients dying each year due to suicide (42). Other risk factors in the field of psychiatry also exist, including personality disorders and substance and alcohol dependence (43,44) and family history of suicide (43,45,46). Race and ethnic group (47), problematic coping skills (48), and environmental variables like recent psychosocial stress (49,50) and occupational problems or interpersonal problems with spouse or romantic partner (51) also constitute risk factors.…”