Heterogeneous associations of multiplexed environmental factors and multidimensional aging metrics
Fan Pu,
Weiran Chen,
Chenxi Li
et al.
Abstract:Complicated associations between multiplexed environmental factors and aging are poorly understood. We manipulated aging using multidimensional metrics such as phenotypic age, brain age, and brain volumes in the UK Biobank. Weighted quantile sum regression was used to examine the relative individual contributions of multiplexed environmental factors to aging, and self-organizing maps (SOMs) were used to examine joint effects. Air pollution presented a relatively large contribution in most cases. We also found … Show more
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