Heterogeneous Cu2O-SnO2 doped polydopamine fenton-like nanoenzymes for synergetic photothermal-chemodynamic antibacterial application

Gao, Jingpi; Yan, Yangyang; Gao, Shegan; Li, Heying; Lin, Xiantao; Cheng, Ji; Hu, Yan; Cai, Kaiyong; Zhang, Xiaozhi; Li, Jinghua

doi:10.1016/j.actbio.2023.11.009

Cited by 24 publications

(3 citation statements)

References 47 publications

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“…Various metallic nanomaterials including monometallic Co NPs, Cu NPs, CoS NSs, chitosan (CS)-Cu-GA NCs, MnO 2 @Ce 6 , ICG@hMnO x , bimetallic Cu 2 O-SnO 2 , MoS 2 /CoS 2 NFs, FeCo@PDA NPs, Cu 1.5 Mn 1.5 O 4 cage-like frame (CF) NSs, cobalt copper glycerate hollow nanospheres (CCG-HNSs), and trimetallic Mo/Fe@CuO 2 have been reported. In this work, bimetallic CuCo/NC exhibits POD-like, OXD-like, photothermal, and photodynamic activities, the MIC value in the CuCo/NC+H 2 O 2 system is 40 μg mL –1 , and the sterilization rate of CuCo/NC-HG+H 2 O 2 +NIR system against MRSA and Amp r E. coli is 99.79 and 99.70%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

Song,

Zhao,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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Superbug infections and transmission have become major challenges in the contemporary medical field. The development of novel antibacterial strategies to efficiently treat bacterial infections and conquer the problem of antimicrobial resistance (AMR) is extremely important. In this paper, a bimetallic CuCo-doped nitrogen−carbon nanozyme-functionalized hydrogel (CuCo/NC-HG) has been successfully constructed. It exhibits photoresponsive-enhanced enzymatic effects under nearinfrared (NIR) irradiation (808 nm) with strong peroxidase (POD)-like and oxidase (OXD)-like activities. Upon NIR irradiation, CuCo/NC-HG possesses photodynamic activity for producing singlet oxygen( 1 O 2 ), and it also has a high photothermal conversion effect, which not only facilitates the elimination of bacteria but also improves the efficiency of reactive oxygen species (ROS) production and accelerates the consumption of GSH. CuCo/NC-HG shows a lower hemolytic rate and better cytocompatibility than CuCo/NC and possesses a positive charge and macroporous skeleton for restricting negatively charged bacteria in the range of ROS destruction, strengthening the antibacterial efficiency. Comparatively, CuCo/NC and CuCo/NC-HG have stronger bactericidal ability against methicillin-resistant Staphylococcus aureus (MRSA) and ampicillin-resistant Escherichia coli (Amp r E. coli) through destroying the cell membranes with a negligible occurrence of AMR. More importantly, CuCo/NC-HG plus NIR irradiation can exhibit satisfactory bactericidal performance in the absence of H 2 O 2 , avoiding the toxicity from high-concentration H 2 O 2 . In vivo evaluation has been conducted using a mouse wound infection model and histological analyses, and the results show that CuCo/NC-HG upon NIR irradiation can efficiently suppress bacterial infections and promote wound healing, without causing inflammation and tissue adhesions.

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Section: Resultsmentioning

confidence: 99%

Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

Song,

Zhao,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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“…14 However, antimicrobial therapy using nanocatalytic antimicrobial agents is still confronted with the limitations of biophysiological conditions, such as relatively high pH conditions (pH = 5–7) and insufficient endogenous H 2 O 2 concentration in the IME, which resulted in poor catalytic efficiency. 15,16 Therefore, how to overcome the limitations of nano-catalyzed antimicrobial agents in the IME and obtain better antimicrobial effects is one of the current hot scientific issues.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of a CeMnOx catalytic gel with bacterial microenvironment-responsive antibacterial properties

Wei,

Niu,

et al. 2024

New J. Chem.

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“…12,13 Fortunately, photothermal therapy (PTT) based on photothermal agents (PTAs), which can convert light energy into heat and realize the killing of bacteria, has attracted wide attention because of its advantages of being non-invasive, non-toxic, and having mild side effects. 14–16 For example, Han et al realized an antibacterial efficiency of 99.99% using near-infrared emitting carbon nanodots (CDs) and peroxalate as chemiluminescence fuels. 17…”

Section: Introductionmentioning

confidence: 99%

Sesame ball-like PTT nanoplatforms with fluorescence-background-free temperature sensing

Bao,

Song,

Yang

et al. 2024

J. Mater. Chem. C

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Heterogeneous Cu2O-SnO2 doped polydopamine fenton-like nanoenzymes for synergetic photothermal-chemodynamic antibacterial application

Cited by 24 publications

References 47 publications

Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

Facile synthesis of a CeMnOx catalytic gel with bacterial microenvironment-responsive antibacterial properties

Sesame ball-like PTT nanoplatforms with fluorescence-background-free temperature sensing

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