2022
DOI: 10.1007/s13577-022-00830-1
|View full text |Cite
|
Sign up to set email alerts
|

Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
7
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
3
1

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(9 citation statements)
references
References 37 publications
2
7
0
Order By: Relevance
“…Fig. 7C ), an effect that has been observed in other tumor types (Avincsal et al, 2021; Sanada et al, 2023). In contrast, ectopic overexpression of ROR2 in the ROR2 Low cell lines HPAF-II and UM32 induced an extensive increase of cell proliferation ( Fig.…”
Section: Resultssupporting
confidence: 73%
“…Fig. 7C ), an effect that has been observed in other tumor types (Avincsal et al, 2021; Sanada et al, 2023). In contrast, ectopic overexpression of ROR2 in the ROR2 Low cell lines HPAF-II and UM32 induced an extensive increase of cell proliferation ( Fig.…”
Section: Resultssupporting
confidence: 73%
“…45 ROR2 expression is regulated in an ASCL1-dependent manner in classic SCLC cell lines, but in an ASCL1-independent manner in variant SCLC cell lines. 39 The heterogeneous expression of ROR2 was observed in SCLC tissues, with high ROR2expressing cells showing more active cell proliferation than low ROR2-expressing cells. RNA-sequence analyses of high ROR2-expressing cells revealed the enrichment of molecules, such as E2F transcription factor 2 (E2F) targets and AURORA KINASES.…”
Section: Significance Of Ascl1 In Sclcmentioning
confidence: 98%
“…RNA-sequence analyses of the two sets of cell lines revealed 120 common ASCL1-associated genes, 30 and based on ChIP-sequence analyses, 14,36 various transcription factors and signal molecules have been proposed as candidate targets of ASCL1, including SRY-box 2 (SOX2), INSM1, ISLET 1, and WNT signal molecules, such as WNT11 and receptor tyrosine kinase-like orphan receptor 2 (ROR2). [37][38][39] As INSM1, a zinc-finger transcriptional factor, was identified as a highly specific marker by microarray gene expression profiling experiments on SCLC cells, 40,41 target molecule of ASCL1, 14,36 the former has been shown to regulate the expression of the latter. 22 Besides the acceleration of NE differentiation in cooperation with ASCL1, INSM1 has been shown to suppress cell proliferation and apoptosis.…”
Section: Significance Of Ascl1 In Sclcmentioning
confidence: 99%
See 2 more Smart Citations