2024
DOI: 10.1101/2024.04.22.24306156
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Heterogeneous metabolomic aging across the same age and prediction of health outcome

Xueqing Jia,
Jiayao Fan,
Xucheng Wu
et al.

Abstract: Existing metabolomic clocks exhibit deficiencies in capturing the heterogeneous aging rates among individuals with the same chronological age. Yet, the modifiable and non-modifiable factors in metabolomic aging have not been systematically studied. Here, we leveraged metabolomic profiles of 239,291 UK Biobank participants for 10-year all-cause mortality prediction to generate and validate a new aging measure--MetaboAgeMort. The MetaboAgeMort showed significant associations with all-cause mortality, cause-speci… Show more

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