Heterogeneous Metal–Organic‐Framework‐Based Biohybrid Catalysts for Cascade Reactions in Organic Solvent

Wang, Yangxin; Zhang, Ningning; Zhang, En; Han, Yunhu; Qi, Zhenhui; Ansorge‐Schumacher, Marion B.; Gao, Yan; Wu, Changzhu

doi:10.1002/chem.201805680

Cited by 71 publications

(55 citation statements)

References 90 publications

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“…Recently, metal–organic frameworks (MOFs) have been demonstrated as a new class of multifunctional nanomaterials or precursors for applications in a wide range of fields . Besides utilizing the MOFs directly to serve as nanocarriers or biocatalysts for biomedical applications, MOF‐derived nanocarbons have also presented intriguing physical and chemical properties, such as high photothermal conversion efficiency, facile doping of metal atoms, and large surface area with porous structures …”

Section: Introductionmentioning

confidence: 99%

Size‐Transformable Metal–Organic Framework–Derived Nanocarbons for Localized Chemo‐Photothermal Bacterial Ablation and Wound Disinfection

Yang

Deng

Huang

et al. 2019

Adv Funct Materials

114

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Severe infectious diseases caused by pathogenic bacteria have become urgent threats to global public health. Antibacterial materials with combined chemophotothermal therapeutic capabilities possess distinct advantages when compared with many other antibacterial approaches. However, developing simplified and chemically tunable precursors to synthesize such antibacterial nanoagents for rapidly, safely, and synergistically combating pathogenic bacteria remains a huge challenge. Herein, metal-organic framework (MOF)-derived nanocarbons with near-infrared (NIR)-responsive and sizetransformable capabilities are designed to overcome this challenge. The MOF-derived nanocarbons with chemo-photothermal bactericidal capabilities are first synthesized, and then coated with a thermoresponsive gel layer to obtain ON-OFF switching capability for bacterial trapping. The fabricated nanocarbons exhibit high photo-to-thermal conversion efficiency and fast size transformation from nanodispersions to micrometer aggregations upon NIR irradiation, thus enabling nanocarbons to generate localized massive heat and abundant Zn 2+ ions for directly disrupting bacterial membrane and intracellular proteins. Furthermore, these nanocarbons not only exhibit a nearly 100% bactericidal ratio at very low dosage, but also possess highly efficient and safe wound disinfection activities, which are comparable to vancomycin. Overall, these proposed novel nanocarbons display robust and localized chemo-photothermal bactericidal capability and possess great potential to be used as alternative to antibiotics for broad-spectrum eradication of pathogenic bacteria.

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Section: Introductionmentioning

confidence: 99%

Size‐Transformable Metal–Organic Framework–Derived Nanocarbons for Localized Chemo‐Photothermal Bacterial Ablation and Wound Disinfection

Yang

Deng

Huang

et al. 2019

Adv Funct Materials

114

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“…The yolk–shell@shell structure of hybrid catalysts allowed complete spatial isolation of metal active sites and enzyme sites, leading to excellent catalytic efficiency in tandem catalysis. More recently, Qi and co‐workers prepared a metal–organic framework–based biohybrid catalyst by stepwise coimmobilizing Pd nanoparticles and CALB on UiO‐66‐NH 2 (Figure e). Compared with the traditional solid supports that have physically fixed structures, MOFs have advantages such as structural flexibility and tunability which are crucial for regulating performances of incorporated catalysts .…”

Section: Synthesis Of Enzyme–metal Hybrid Catalysts (Emhcs)mentioning

confidence: 99%

Section: Synthesis Of Enzyme–metal Hybrid Catalysts (Emhcs)mentioning

confidence: 99%

Enzyme–Metal Hybrid Catalysts for Chemoenzymatic Reactions

Cao

Xiong

et al. 2019

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“…(Hartmann and Jung, 2010;Datta et al, 2013;Zhou and Hartmann, 2013). The immobilization can be approached by different techniques, e.g., adsorption (Wang et al, 2019), covalent binding (Engstrom et al, 2013), affinity immobilization (Keller et al, 2017), and entrapment (Majewski et al, 2017). Generally, the stability of immobilized enzymes is usually enhanced compared with free enzymes, which thus enables the long-term and repeated usage of the enzymes.…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Enzyme-Embedded Metal–Organic Frameworks for Size-Selective Biocatalysis in Organic Solvent

Wang

Zhang

Tan

et al. 2020

Front. Bioeng. Biotechnol.

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In situ immobilization of enzyme into metal-organic frameworks (MOFs) is performed through a one-step and facile method. Candida antarctica lipase B (CalB) is directly embedded in zeolitic imidazolate framework (ZIF)-8 by simply mixing an aqueous solution of 2-methylimidazole and zinc nitrate hexahydrate [Zn(NO 3) 2 •6H 2 O] containing CalB at room temperature. Due to the intrinsic micropores of ZIF-8, the obtained CalB@ZIF composite is successfully applied in size-selective transesterification reaction in organic solvent. CalB@ZIF not only shows much higher catalytic activity but also exhibits higher thermal stability than free CalB. Besides, the robust ZIF-8 shell also offers the hybrid composites excellent reusability.

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Heterogeneous Metal–Organic‐Framework‐Based Biohybrid Catalysts for Cascade Reactions in Organic Solvent

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.

Cited by 71 publications

References 90 publications

Size‐Transformable Metal–Organic Framework–Derived Nanocarbons for Localized Chemo‐Photothermal Bacterial Ablation and Wound Disinfection

Size‐Transformable Metal–Organic Framework–Derived Nanocarbons for Localized Chemo‐Photothermal Bacterial Ablation and Wound Disinfection

Enzyme–Metal Hybrid Catalysts for Chemoenzymatic Reactions

Facile Synthesis of Enzyme-Embedded Metal–Organic Frameworks for Size-Selective Biocatalysis in Organic Solvent

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