Heterogeneous motor BOLD-fMRI responses in brain areas exhibiting negative BOLD cerebrovascular reactivity indicate that steal phenomenon does not always result from exhausted cerebrovascular reserve capacity

Niftrik, Christiaan Hendrik Bas van; Hiller, Aimee; Sebök, Martina; Halter, Matthias; Duffin, James; Fisher, Joseph A.; Mikulis, David J.; Regli, Luca; Piccirelli, Marco; Fierstra, Jorn

doi:10.1016/j.mri.2023.07.010

Cited by 2 publications

(2 citation statements)

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“…In healthy aging subjects, CVR has been shown to differ across brain regions, with CVR in particular regions such as the hippocampus being associated with memory scores ( Catchlove et al, 2018 ). The heterogeneous nature of CVR has been reported in previous studies ( D. Y. Chen, Di, & Biswal, 2024 ; D. Y. Chen, Di, Yu, et al, 2024 ; Kastrup et al, 1999 ; Moia et al, 2020 ; van Niftrik et al, 2023 ); however, it is unclear whether a measure of the heterogeneity of CVR may reveal vascular pathologies in the brain, particularly in patient populations.…”

Section: Discussionmentioning

confidence: 88%

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Delayed cerebrovascular reactivity in individuals with spinal cord injury in the right inferior parietal lobe: a breath-hold functional near-infrared spectroscopy study

Chen,

Di,

Karunakaran

et al. 2024

Preprint

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Cerebrovascular reactivity (CVR) reflects the ability of blood vessels to dilate or constrict in response to a vasoactive stimulus, and allows researchers to assess the brain’s vascular health. Individuals with spinal cord injury (SCI) are at an increased risk for autonomic dysfunction in addition to cognitive impairments, which have been linked to a decline in CVR; however, there is currently a lack of brain-imaging studies that investigate how CVR is altered after SCI. In this study, we used a breath-holding hypercapnic stimulus and functional near-infrared spectroscopy (fNIRS) to investigate CVR alterations in individuals with SCI (n = 20, 14M, 6F, mean age = 46.3 ± 10.2 years) as compared to age– and sex-matched able-bodied (AB) controls (n = 25, 19M, 6F, mean age = 43.2 ± 12.28 years). CVR was evaluated by its amplitude and delay components separately by using principal component analysis and cross-correlation analysis, respectively. We observed significantly delayed CVR in the right inferior parietal lobe in individuals with SCI compared to AB controls (linear mixed-effects model, fixed-effects estimate = 6.565, Satterthwaite’s t-test, t = 2.663, p = 0.008), while the amplitude of CVR was not significantly different. The average CVR delay in the SCI group in the right inferior parietal lobe was 14.21 s (sd: 6.60 s), and for the AB group, the average delay in the right inferior parietal lobe was 7.08 s (sd: 7.39 s). CVR delays were also associated with the duration since injury in individuals with SCI, in which a longer duration since injury was associated with a shortened delay in CVR in the right inferior parietal region (Pearson’s r-correlation, r = –0.59, p = 0.04). This study shows that fNIRS can be used to quantify changes in CVR in individuals with SCI, and may be further used in rehabilitative settings to monitor the cerebrovascular health of individuals with SCI.

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Section: Discussionmentioning

confidence: 88%

“…D. Y. Chen, Di, Yu, et al, 2024;Kastrup et al, 1999;Moia et al, 2020;van Niftrik et al, 2023); however, it is unclear whether a measure of the heterogeneity of CVR may reveal vascular pathologies in the brain, particularly in patient populations.…”

Section: Variability In Cvr Across the Brainmentioning

confidence: 99%