Reliability issues such as a soft error and NBTI (negative bias temperature instability) have become a matter of concern as integrated circuits continue to shrink. It is getting more and more important to take reliability requirements into account even for consumer products. This paper presents a dynamic continuous signature monitoring (DCSM) technique for high reliable computer systems. The DCSM technique dynamically generates reference signatures as well as runtime ones during executing a program. The DCSM technique stores the generated signatures in a signature table, which is a small storage circuit in a microprocessor, unlike the conventional static continuous signature monitoring techniques and contributes to saving program or data memory space that stores the signatures. Our experiments showed that our DCSM technique protected 1.4-100.0% of executed instructions depending on the size of signature tables.