Heterogeneous Nuclear Protein U Degraded the m
            <sup>6</sup>
            A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication

Zhou, Haoran; Yan, Yuchao; Gao, Jie; Ma, Mingrui; Liu, Yi; Shi, Xiaojie; Zhang, Qi; Xu, Xiaoxiao

doi:10.1128/jvi.01751-22

Cited by 9 publications

(1 citation statement)

References 45 publications

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“…However, Gupta et al ( 81 ) found that SAF-A is associated with the leader RNA of VSV and co-localizes with the virus in the cytoplasm of infected cells, implying that SAF-A may contribute to the life cycle of VSV and its pathogenesis. In recent studies, SAF-A was found to negatively regulate innate immune responses against infectious bursal disease viruses and porcine epidemic diarrhea virus and induce immune escape of these viruses ( 82 , 83 ).…”

Section: Clinical Significance Of Saf-amentioning

confidence: 99%

Biological functions and clinic significance of SAF‑A (Review)

Zhang,

Li,

et al. 2024

Biomed Rep

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As one member of the heterogeneous ribonucleoprotein (hnRNP) family, scaffold attachment factor A (SAF-A) or hnRNP U, is an abundant nuclear protein. With RNA and DNA binding activities, SAF-A has multiple functions. The present review focused on the biological structure and different roles of SAF-A and SAF-A-related diseases. It was found that SAF-A maintains the higher-order chromatin organization via RNA and DNA, and regulates transcription at the initiation and elongation stages. In addition to regulating pre-mRNA splicing, mRNA transportation and stabilization, SAF-A participates in double-strand breaks and mitosis repair.Therefore, the aberrant expression and mutation of SAF-A results in tumors and impaired neurodevelopment. Moreover, SAF-A may play a role in the anti-virus system. In conclusion, due to its essential biological functions, SAF-A may be a valuable clinical prediction factor or therapeutic target. Since the role of SAF-A in tumors and viral infections may be controversial, more animal experiments and clinical assays are needed. Contents 1. Introduction 2. Materials and methods 3. The structure of SAF-A 4. Functions of SAF-A 5.

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Section: Clinical Significance Of Saf-amentioning

confidence: 99%

Biological functions and clinic significance of SAF‑A (Review)

Zhang,

Li,

et al. 2024

Biomed Rep

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show abstract

Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA

Aufgebauer,

Bland,

Horner

2024

Cell Chemical Biology

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Porcine epidemic diarrhea virus: A review of detection, inhibition of host gene expression and evasion of host innate immune

Ma,

Zheng,

Chen

et al. 2024

Microbial Pathogenesis

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Heterogeneous Nuclear Protein U Degraded the m ⁶ A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication

Abstract: PEDV, a highly infectious enteric coronavirus, has spread rapidly worldwide and caused severe economic losses. During virus infection, the host regulates innate immunity to inhibit virus infection.

Cited by 9 publications

References 45 publications

Biological functions and clinic significance of SAF‑A (Review)

Biological functions and clinic significance of SAF‑A (Review)

Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA

Porcine epidemic diarrhea virus: A review of detection, inhibition of host gene expression and evasion of host innate immune

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Heterogeneous Nuclear Protein U Degraded the m 6 A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication

Abstract: PEDV, a highly infectious enteric coronavirus, has spread rapidly worldwide and caused severe economic losses. During virus infection, the host regulates innate immunity to inhibit virus infection.

Cited by 9 publications

References 45 publications

Biological functions and clinic significance of SAF‑A (Review)

Biological functions and clinic significance of SAF‑A (Review)

Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA

Porcine epidemic diarrhea virus: A review of detection, inhibition of host gene expression and evasion of host innate immune

Contact Info

Product

Resources

About

Heterogeneous Nuclear Protein U Degraded the m ⁶ A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication