Heterogeneous oncologic outcomes according to surgical pathology in high-risk prostate cancer: implications for better risk stratification and preoperative prediction of oncologic outcomes

Choi, Seung-Kwon; Shim, Myungsun; Kim, Myong; Park, Myungchan; Lee, Sangmi; Song, Cheryn; Lee, Hyung-Lae; Ahn, Hanjong

doi:10.1007/s00432-017-2437-z

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…at present, there are various methods for the treatment of prostate cancer, including surgical treatment, hormone therapy, radiotherapy, etc. although these methods are widely used in clinical treatment, there are several limitations in the treatment and prognosis of prostate cancer (12)(13)(14). Therefore, research has recently paid more attention to the prevention and treatment of prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

miR‑589‑5p is downregulated in prostate cancer and regulates tumor cell viability and metastasis by targeting CCL‑5

Jiang

Mao

et al. 2019

Mol Med Report

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Prostate cancer is one of the most common human malignancies, which represents a serious threat to health, and micrornas (mirnas/mirs) have been reported to be closely associated with the progression and development of prostate cancer. The present study aimed to investigate the expression patterns, functions and underlying mechanisms of mir-589-5p in prostate cancer. The results demonstrated that the expression levels of mir-589-5p were downregulated in prostate cancer tissues and cell lines. overexpression of mir-589-5p inhibited cell viability, migration and invasion in prostate cancer cells. Subsequently, chemokine (c-c motif) ligand 5 (CCL-5) was identified as a direct target gene of miR-589-5p, which was highly expressed at the mrna and protein levels in prostate cancer tissues and cells. Furthermore, ccl-5 mrna was negatively correlated with mir-589-5p expression in prostate cancer tissues. Silencing ccl-5 promoted the apoptosis, and inhibited the migration and invasion of prostate cancer cells. Taken together, these results indicated that mir-589-5p may act as a tumor suppressor in prostate cancer by targeting ccl-5, thus suggesting that mir-589-5p may be a novel and reliable molecular marker for the diagnosis and prognosis of prostate cancer.

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Section: Introductionmentioning

confidence: 99%

miR‑589‑5p is downregulated in prostate cancer and regulates tumor cell viability and metastasis by targeting CCL‑5

Jiang

Mao

et al. 2019

Mol Med Report

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“…We used molecular cancer pro les to stratify patients in cancer informatics studies due to the complexity and heterogeneous of this disease [49]. Based on our earlier results that demonstrated the remarkable prognostic values of immune-related lncRNAs, we investigated whether these immune-related lncRNAs are capable of classifying LUAD patients into clinically-relevant subtypes.…”

Section: Strati Cation Of Luad Patients Based On Candidate Immunerelated Lncrnamentioning

confidence: 99%

Identification of Immune-Related lncRNA Biomarkers Associated With Prognosis In LUAD

Guo¹,

Shao²,

Han

et al. 2021

Preprint

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Background: Long non-coding RNAs (lncRNAs) are involved in regulation of immune response and could serve as biomarkers for tumors. Methods: WGCNA were used to construct an immune-related gene interaction network and elucidated possible functions of the lncRNAs by gene enrichment analyses. 6 lncRNAs were selected and used to construct an immune-related lncRNAs risk score (ILRS) classifier. Results: Patients with high and low ILRS showed significant differences in microenvironment and immune cell infiltration type. Furthermore, enrichment analyses showed that these lncRNAs regulated immune-related pathways. Finally, four clusters derived from LUAD patients showed a significant correlation with overall survival of patients. Conclusions: This work provide new insights for subsequent development of clinical strategies against the disease.

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Heterogeneous oncologic outcomes according to surgical pathology in high-risk prostate cancer: implications for better risk stratification and preoperative prediction of oncologic outcomes

Abstract: Using our scoring system, we can predict which patients with high-risk PCa would benefit more from RP. Thus, this system can be used in patient counseling to determine an optimal treatment strategy for high-risk PCa.

Cited by 2 publications

References 28 publications

miR‑589‑5p is downregulated in prostate cancer and regulates tumor cell viability and metastasis by targeting CCL‑5

miR‑589‑5p is downregulated in prostate cancer and regulates tumor cell viability and metastasis by targeting CCL‑5

Identification of Immune-Related lncRNA Biomarkers Associated With Prognosis In LUAD

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