Heterogeneous origin of IgE in atopic dermatitis and psoriasis revealed by B cell receptor repertoire analysis

Luo, Lihua; Luo, Yadong; Xu, Jing; Zhu, Ronghui; Wu, Jinghua; Liu, Xiao; Li, Wei; Xu, Yao

doi:10.1111/all.15173

Cited by 15 publications

(22 citation statements)

References 29 publications

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“…MCs can directly bind to immature dendritic cells (DCs), induce increased expression levels of the costimulators CD86, CD80, and CD40 on the DC surface, indicating DC maturation, and promote the release of T cell-modulating cytokines, such as IFN-γ, IL-12, IL-6, and TGF-β, enhancing the ability of DCs to induce the proliferation of CD4+ T cells and Th1 and Th17 polarization ( 14 ). Increased IL-17A induces IgG memory B cells to produce IgE by class-switch recombination, forming immune complexes containing soluble IgE with psoriasis-associated autoantigens; these are presented to plasmacytoid (p) DCs via FcϵRI, activating pDCs to trigger inflammatory cytokine responses, including IFN-α, IL-6, IL-8, and TNF, involved in the development and maintenance of inflammatory processes in psoriatic lesions ( 15 – 17 ). Future studies are needed to determine how IgE-FcϵRI interactions precisely affect the activation of multiple immune cells in psoriatic skin lesions.…”

Section: Mast Cells In Psoriasismentioning

confidence: 99%

Mast cells as important regulators in the development of psoriasis

Zhou

Chen²,

Zhang³

2022

Front. Immunol.

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Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The current review describes interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis to emphasize the important role of mast cell-centered cell networks in psoriasis.

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Section: Mast Cells In Psoriasismentioning

confidence: 99%

Mast cells as important regulators in the development of psoriasis

Zhou

Chen²,

Zhang³

2022

Front. Immunol.

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“…In mouse models, there are two types of IgE induced via natural and adaptive ways ( 178 ). Adaptive IgE is usually produced by B cells and plasma cells, with characteristics such as variable region gene polysomatic high mutation.…”

Section: Ige Is a Link Or Epiphenomena For Atopic Dermatitis And Psor...mentioning

confidence: 99%

“…Therefore, B cells that naturally produce IgE have less polysomatic high mutation and can respond to their own antigens ( 179 ). Some studies have found that high IgE VH mutation and the increased CDR3 diversity along with high serum IgE content in AD and psoriasis patients ( 178 ). In addition, it was found that the serum IgE level of Sequestosome 1/ P62 DKO mice returned to be normal, which was increased in psoriatic lesions, suggesting that this gene has a similar IgE regulation mechanism in psoriasis and AD ( 180 ).…”

Section: Ige Is a Link Or Epiphenomena For Atopic Dermatitis And Psor...mentioning

confidence: 99%

Elevation of IgE in patients with psoriasis: Is it a paradoxical phenomenon?

Shi

Liu²,

Xiong

et al. 2022

Front. Med.

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Immunoglobulin E (IgE) elevation is a hallmark of allergic conditions such as atopic dermatitis (AD). The pathogenesis of AD is typically associated with high levels of IL-4 and IL-13 produced by activated T helper 2 (Th2) cells. Psoriasis, on the other hand, is an inflammatory skin disease mainly driven by Th17 cells and their related cytokines. Although the immunopathologic reactions and clinical manifestations are often easily distinguished in the two skin conditions, patients with psoriasis may sometimes exhibit AD-like manifestations, such as elevated IgE and persistent pruritic lesions. Given the fact that the effective T cells have great plasticity to re-differentiate in response to innate and environmental factors, this unusual skin condition could be a consequence of a cross-reaction between distinct arms of T-cell and humoral immunity. Here we review the literature concerning the roles of IgE in the development of AD and psoriasis, showing that elevated IgE seems to be an important indicator for this non-typical psoriasis.

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“…It is believed that psoriasis is a disease that is not associated with atopic dermatitis, as evidenced by their extremely rare coexistence [ 6 , 7 ]. However, it does not exclude the coexistence of, for example, an allergy to environmental, food, or contact allergens, which is a factor in individual works [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Immunological and Allergen Profiles of Patients with Atopic Dermatitis or Psoriasis

2022

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Background and objectives: Atopic dermatitis (AD) and psoriasis (PS) are systemic inflammatory diseases with complex and distinct immune mechanisms. That the same factors may aggravate both diseases cannot be ruled out. The aim of this study was to assess the potential differences between a sensitization to inhaled allergens and the immunological profiles of patients diagnosed with AD and PS in comparison with healthy controls. Materials and methods: A total of 139 patients with AD, 115 with PS, and 142 controls were included in the prospective study. Patients were eligible if they were diagnosed with mild to severe AD or PS and between 18 and 65 years of age. In all the participants, the serum concentrations of specific IgE (sIgE) for common inhaled allergens were measured. In all the subjects, the cytokine serum blood profiles for TNF-α, IFN-γ, Il-2, Il-4, Il-5, Il-6, Il-8, Il-12, Il-17, Il-18, Il-22, and Il-24 were measured via an ELISA. Results: The patients with AD had positive sIgE results more frequently than the patients with PS and the controls (113 vs. 36 vs. 21, respectively). A sensitization to mites was dominant in the patients with AD (p < 0.05), and a sensitization to Aspergillus was dominant in the patients with PS (p < 0.05). The patients with multiple allergies to inhaled allergens had a lower risk of developing PS (OR = 0.65; 95% CI: 0.43–0.86) but a greater risk of severe AD (OR = 3.77; 95% CI: 3.25–3.96). The mean concentrations of the most tested cytokines were comparable in the patients with AD and PS. However, high serum concentrations of Il-4, Il-5, and Il-6 were only dominant in the AD group. There were no relationships between the increased serum concentrations of individual cytokines and allergies to the individually examined allergens. Conclusion: Inhalation-dependent IgE sensitizations were prevalent in the AD patients but were also possible in the PS patients; they were often without clinical manifestations in the latter group. The investigated cytokine profiles indicated their high convergence in the studied patients and confirmed the active inflammatory nature of AD and PS.

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Heterogeneous origin of IgE in atopic dermatitis and psoriasis revealed by B cell receptor repertoire analysis

Cited by 15 publications

References 29 publications

Mast cells as important regulators in the development of psoriasis

Mast cells as important regulators in the development of psoriasis

Elevation of IgE in patients with psoriasis: Is it a paradoxical phenomenon?

The Immunological and Allergen Profiles of Patients with Atopic Dermatitis or Psoriasis

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