Heterogeneous porosity design triggered stress reorganization to avoid intervertebral cage subsidence and promote spinal fusion

Pei, Xuan; Wang, Linnan; Wu, Lina; Lei, Haoyuan; Feng, Pin; Fan, Chen; Zhou, Zhigang; Wang, Lei; Liu, Ming; Zhou, Changchun; Kong, Qingquan; Fan, Yujiang

doi:10.1016/j.compstruct.2023.117516

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…As a common implant in orthopedics, titanium alloy has excellent compatibility with bone tissue, and can be used as a permanent implant [ 54 , 55 ]. In addition, the pore structure of titanium alloy scaffold is conducive to the growth of new bone tissues [ 56 ]. This makes the scaffold-bone structure share the local stress, which can reduce the risk of scaffold damage and increase the stability of bone.…”

Section: Resultsmentioning

confidence: 99%

Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis

Li,

Cui,

Liu

et al. 2024

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis

Li,

Cui,

Liu

et al. 2024

Materials Today Bio

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“…Bone defects caused by severe trauma or disease and self-healing failures remain significant challenges in the field of orthopedics . At present, the main methods for treating bone defects in clinical practice are autologous bone transplantation, allogeneic bone transplantation, and other bone substitute material transplantation, but these have their own drawbacks. − Bone tissue engineering aims to use bone regeneration repair materials (scaffolds), cells, and appropriate molecules or physical factors alone or in combination to repair or replace bone tissue to improve treatment outcomes . Considering that biomaterials containing cells or growth factors require strict regulatory review, lengthy clinical transformation, and the immunogenicity and biological risks of biological components, researchers are now paying more attention to the biological effects brought by the components and structures of biomaterial scaffolds .…”

Section: Introductionmentioning

confidence: 99%

DLP Fabrication of Multiple Hierarchical Biomimetic GelMA/SilMA/HAp Scaffolds for Enhancing Bone Regeneration

Song,

Gui,

et al. 2024

Biomacromolecules

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Severe bone defects resulting from trauma and diseases remain a persistent clinical challenge. In this study, a hierarchical biomimetic microporous hydrogel composite scaffold was constructed by mimicking the hierarchical structure of bone. Initially, gelatin methacrylamide (GelMA) and methacrylic anhydride silk fibroin (SilMA) were synthesized, and GelMA/ SilMA inks with suitable rheological and mechanical properties were prepared. Biomimetic micropores were then generated by using an aqueous two-phase emulsification method. Subsequently, biomimetic microporous GelMA/SilMA was mixed with hydroxyapatite (HAp) to prepare biomimetic microporous GelMA/ SilMA/HAp ink. Hierarchical biomimetic microporous GelMA/ SilMA/HAp (M-GSH) scaffolds were then fabricated through digital light processing (DLP) 3D printing. Finally, in vitro experiments were conducted to investigate cell adhesion, proliferation, and inward migration as well as osteogenic differentiation and vascular regeneration effects. In vivo experiments indicated that the biomimetic microporous scaffold significantly promoted tissue integration and bone regeneration after 12 weeks of implantation, achieving 42.39% bone volume fraction regeneration. In summary, this hierarchical biomimetic microporous scaffold provides a promising strategy for the repair and treatment of bone defects.

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Toward Novel Porous Boronized Ti6Al4V/FHA Composite Implants by Combined Microwave Sintering and Temporary Space Alloying

Zuo,

Luo,

Peng

et al. 2024

Small Structures

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Titanium alloys are unsuitable implants for patients with low bone quality due to their high moduli and bioinertness. In this study, porous boronized Ti6Al4V/fluorohydroxyapatite (FHA) composites are synthesized via microwave sintering of mixed Ti6Al4V, FHA and TiB2 powders at 1050 °C for 30 min, with 0–10 wt% urea as a space holder material. It is shown that increasing urea addition leads to higher porosity, promoting microwave penetration and microwave “lens effect”, which improves boronization and restrains degradation of mechanical properties of the composites caused by the increased porosity. With the urea addition of 0–3 wt%, the compressive strength and modulus decrease from 380.3 MPa and 14.5 GPa to 134.4 MPa and 3.26 GPa, respectively, while the Vickers microhardness declines from 360.3 to 300.0 HV. The increased exposure of FHA improves chemical and biological properties of the composite, with water contact angle decreased by nearly half and osteogenesis increased by sixfold. By adding more urea, the microhardness decreases evidently, with poorer wettability and biocompatibility due to looser structure and FHA decomposition. By adding 3 wt% urea, the composite achieves an optimal balance between ultralow modulus and enhanced bioactivity, making it ideal for rapid osseointegration in patients with poor bone conditions.

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Heterogeneous porosity design triggered stress reorganization to avoid intervertebral cage subsidence and promote spinal fusion

Cited by 6 publications

References 37 publications

Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis

Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis

DLP Fabrication of Multiple Hierarchical Biomimetic GelMA/SilMA/HAp Scaffolds for Enhancing Bone Regeneration

Toward Novel Porous Boronized Ti6Al4V/FHA Composite Implants by Combined Microwave Sintering and Temporary Space Alloying

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