Heterogeneous surface architectured metal-organic frameworks for cancer therapy, imaging, and biosensing: A state-of-the-art review

Pandey, Abhijeet; Dhas, Namdev; Deshmukh, Prashant K.; Caro, Carlos; Patil, Pravin O.; García-Martín, María Luisa; Padya, Bharath Singh; Nikam, Ajinkya Nitin; Mehta, Tejal; Mutalik, Srinivas

doi:10.1016/j.ccr.2020.213212

Cited by 112 publications

(72 citation statements)

References 333 publications

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“…Between these values, the materials can show dual contrast characteristics. 126 MRI is a powerful imaging modality, however it requires the administration of contrast agents in large doses to enable adequate MRI contrast in target tissues. 38 For clinical applications, the most widely used MRI contrast agents are paramagnetic gadolinium (Gd) chelates, which act as T1 contrast agents producing signal enhancement in T1-weighted images.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine

Duman

Forgan

2021

J. Mater. Chem. B

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine

Duman

Forgan

2021

J. Mater. Chem. B

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“…Wetted material was extruded by using RAM extruder followed by 3D printing of orodispersible films on packing material. [9][10][11][12][13][14] Jamróz et al prepared an orodipersible film of poorly water-soluble drugaripiprazole for improvement of dissolution rate. After the processing, aripiprazole is converted into amorphous form in product as confirmed by XRD data.…”

Section: B Orodispersible Filmsmentioning

confidence: 99%

Three Dimensional Printing by Hot-Melt Extrusion; New Era for Development of Personalized Medicines and Continuous Manufacturing of Pharmaceuticals

Chivate

Garkal

Dhas

et al. 2020

IJPI

Self Cite

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The three-dimensional printing is a growing field in engineering, civil constructions and pharmaceutical development. The three-dimensional printing is a one-step continuous process. However, conventional manufacturing is batch by batch process hence the three-dimensional manufacturing is advantageous over conventional manufacturing. The three-dimensional technique is cost effective and time-saving process. The three-dimensional printing is a rising era in the development and manufacturing of pharmaceuticals such as medical devices, oral dosage forms and some modified-release products. The personalized dose adjustment as per patient requirement is easier due to three dimensional printing. Hence, the personalized dosage forms are more preferable for potent drugs to avoid the adverse drug reactions and accuracy of a therapeutic drug. The three-dimensional technique equipped with hot-melt extrusion is recently used for the development of various pharmaceutical products. The fused disposition model is commonly employed for the development of layer by layer products. However, the hot-melt extrusion was previously used in pharmaceuticals for solubility enhancement. Currently ample of applications of hot-melt extrusion is explored in research and one of them is the manufacturing of personalized pharmaceuticals. The dose adjustment and personalized pharmaceutical development will be achieved by three dimensional technique equipped with hot-melt extrusion. There is a wide range of polymeric materials with superior properties available for three-dimensional printing of pharmaceuticals. This review briefly discussed the applications of three-dimensional techniques for pharmaceutical development with suitable examples. The current scenario of the techniques and future perspectives are also discussed.

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“…Furthermore, readers are referred to the existing reviews for the deeper knowledge on employing MOFs as scaffolds for PDT related applications. [30][31][32][33][34][35][36][37][38][39][40] However, this concept article is restricted to those cases where Au NPs embedded inside MOFs used for PDT applications.…”

Section: Introductionmentioning

confidence: 99%

“…The existing literature data have been arranged based on the type of material and a final section provides the current state of the art and comment on future prospects. Furthermore, readers are referred to the existing reviews for the deeper knowledge on employing MOFs as scaffolds for PDT related applications [30–40] . However, this concept article is restricted to those cases where Au NPs embedded inside MOFs used for PDT applications.…”

Section: Introductionmentioning

confidence: 99%

Gold‐Nanoparticle‐Decorated Metal‐Organic Frameworks for Anticancer Therapy

et al. 2020

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Confinement of Au nanoparticles (NPs) within the porous materials with few nanometers (2-3 nm) has been a well established research area in the past decades in heterogeneous catalysis mainly due to the unique behaviour of Au NPs than its bulk counterpart. In this aspect, Au NPs encapsulated within the pore volumes of metalÀ organic frameworks (MOFs) have been intensively explored as heterogeneous solid catalysts for wide range of reactions. In recent years, Au NPs confined within the porous MOFs along with the photosensitizer or drug have been effectively used for the treatment of tumor cells through the generation of reactive oxygen species via cascade reactions. This work highlights the benefits of MOFs pores in the preparation of nanomedicine with high efficiency by assembling Au NPs, photosensitizer/drug with the combination of laser either for imaging or treatment of tumor cells. Further, the existing literature is grouped based on the nature of porous materials employed in the preparation of nanomedicine. The final section comments on our view on future developments in the field.

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Heterogeneous surface architectured metal-organic frameworks for cancer therapy, imaging, and biosensing: A state-of-the-art review

Cited by 112 publications

References 333 publications

Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine

Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine

Three Dimensional Printing by Hot-Melt Extrusion; New Era for Development of Personalized Medicines and Continuous Manufacturing of Pharmaceuticals

Gold‐Nanoparticle‐Decorated Metal‐Organic Frameworks for Anticancer Therapy

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