Heterogeneous synthesis of nitrogen-doped carbon dots prepared via anhydrous citric acid and melamine for selective and sensitive turn on-off-on detection of Hg (II), glutathione and its cellular imaging

Iqbal, Anam; Iqbal, Kanwal; Xu, Lingbo; Li, Bo; Gong, Deyan; Liu, Xiaoyu; Guo, Yali; Liu, Weisheng; Qin, Wenwu; Guo, Huichen

doi:10.1016/j.snb.2017.08.130

Cited by 131 publications

(57 citation statements)

References 31 publications

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“…Bhattacharya et al also used aminoguanidine based CDs for nitric oxide (NO) detection via formation of azo dye [ 132 ]. Recently Iqbal et al fabricated N-doped CDs from citric acid and melamine (passivation agent) and applied them for sensing glutathione and Hg 2+ in the biological system via fluorescence quenching [ 133 ].…”

Section: Applications Of Cdsmentioning

confidence: 99%

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

2019

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Carbon dots (CDs) are the new fellow of carbon family having a size less than 10 nm and attracted much attention of researchers since the last decade because of their unique characteristics, such as inexpensive and facile synthesis methods, easy surface modification, excellent photoluminescence, outstanding water solubility, and low toxicity. Due to these unique characteristics, CDs have been extensively applied in different kind of scientific disciplines. For example in the photocatalytic reactions, drug-gene delivery system, in vitro and in vivo bioimaging, chemical and biological sensing as well as photodynamic and photothermal therapies. Mainly two types of methods are available in the literature to synthesize CDs: the top-down approach, which refers to breaking down a more massive carbon structure into nanoscale particles; the bottom-up approach, which refers to the synthesis of CDs from smaller carbon units (small organic molecules). Many review articles are available in the literature regarding the synthesis and applications of CDs. However, there is no such review article describing the synthesis and complete application of CDs derived from small organic molecules together. In this review, we have summarized the progress of research on CDs regarding its synthesis from small organic molecules (bottom-up approach) via hydrothermal/solvothermal treatment, microwave irradiation, ultrasonic treatment, and thermal decomposition techniques as well as applications in the field of bioimaging, drug/gene delivery system, fluorescence-based sensing, photocatalytic reactions, photo-dynamic therapy (PDT) and photo-thermal (PTT) therapy based on the available literature. Finally, the challenges and future direction of CDs are discussed.

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Section: Applications Of Cdsmentioning

confidence: 99%

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

2019

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“…Owing to their exceptional advantages, which include biocompatibility, facile synthesis, and adjustable strong fluorescence performance, citrate-based CDs have recently drawn increasing attention for use in biomedical applications, such as bioimaging, [39, 72] biosensing, [37, 41] and biomedicine, [73] as described following.…”

Section: Citrate-based Carbon Dots (Cds)mentioning

confidence: 99%

“…[37, 44, 46, 75] For instance, Zhang et al synthesized from CA and urea a type of green CDs, which showed high fluorescence QY of 25.4%, good water solubility, and excellent photostability. [46] The green CDs showed significant and selective quenching by curcumin due to the inner filter effect.…”

Section: Citrate-based Carbon Dots (Cds)mentioning

confidence: 99%

“…The developed citrate-based fluorescent materials, which included CDs, BPLPs, and molecular fluorophores, presented favorable biocompatibility/biodegradability, and strong and stable fluorescence, enabling their use in important biomedical applications, such as bioimaging, [31, 33, 37–43] biosensing, [37, 44–48] and nanomedicine. [49–51] For example, NIR-imaging information encryption and in vivo NIR fluorescence imaging of the stomach of a living mouse were achieved using citrate-based CDs synthesized from CA and urea.…”

Section: Introductionmentioning

confidence: 99%

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Citrate‐Based Fluorescent Biomaterials

Shan

Hsieh

Bai

et al. 2018

Adv Healthcare Materials

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Fluorescence imaging has emerged as a promising technique for monitoring and assessing various biologically relevant species in cells and organisms, driving the demand for effective fluorescent agents with good biocompatibility and high fluorescence performance. However, traditional fluorescent agents, such as quantum dots (QDs) and organic dyes, either suffer from toxicity concerns or poor fluorescence performance (e.g., low photobleaching-resistance). In this regard, citrate-based fluorescent biomaterials, which are synthesized from the natural and biocompatible precursor of citric acid (CA), have become competitive alternatives for fluorescence imaging owing to their biocompatibility, cost effectiveness, straightforward synthetic routes, flexible designability, as well as strong fluorescence with adjustable excitation/emission wavelengths. Accordingly, numerous citrate-based biomaterials, including carbon dots (CDs), biodegradable photoluminescent polymers (BPLPs), and small molecular fluorophores, have been developed and researched in the past few decades. This review discusses recent progress in the research and development of citrate-based fluorescent materials with emphasis on their design and synthesis considerations, material properties, fluorescence properties and mechanisms, as well as biomedical applications. It is expected that this review will provide an insightful discussion on the citrate-based fluorescent biomaterials, and lead to innovations for the next generation of fluorescent biomaterials and fluorescence-based biomedical technology.

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“…The use of cancer specific targeting residues (e.g. antibodies, ligands, and lectins) can also achieve tumor cell targeting [34][35][36][37][38][39][40][41][42][43].…”

Section: For Cancer Treatmentmentioning

confidence: 99%

Recent Revolutions in Nanoscience and Nanotechnology with Its Application’s

2019

ANN

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During the past decade, new directions of modern research, broadly defined as nanoscale science and technology have emerged. This is not a separate scientific field; instead it is a complex platform for the existing disciplines of biology, physics, medicine, chemistry, neurology, engineering, information technology, and a newmultidisciplinary scientific research area. In recent years, the nanoscience and nanotechnology have attract a great deal of attention in both synthesis methodologies and wide applications of medicine, energy, environmental, electronics etc. Despite of significant progress in nanotechnology and rise of many commercialized products involving nanomaterials, nanoscience, and technology are still facing many new challenges, especially in the areas of great concern to the public i.e. energy and health.

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Heterogeneous synthesis of nitrogen-doped carbon dots prepared via anhydrous citric acid and melamine for selective and sensitive turn on-off-on detection of Hg (II), glutathione and its cellular imaging

Cited by 131 publications

References 31 publications

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

Citrate‐Based Fluorescent Biomaterials

Recent Revolutions in Nanoscience and Nanotechnology with Its Application’s

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