Heterogenous uptake on brain SPECT

Shih, Wei-Jen; Wilson, Douglas; Stipp, Vickie; Ashford, J. Wesson

doi:10.1016/s0001-2998(99)80034-8

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…From the SPECT of CAA patients included in our study, we were able to observe multifocal hypoperfusion in both cerebral cortical regions, which corresponded well with the report by Shih et al (9). Decreased regional CBF in both basal ganglia was reported many times but confirmed for the first time through SPECT in this study.…”

Section: Discussionsupporting

confidence: 92%

“…Shih et al obtained 99m Tc-HMAPO images from a 71-y-old man with CAA and reported heterogeneous uptake of the radiotracer. These findings may reflect multiple foci of decreased perfusion that occurs from stenosis or occlusion of small-and medium-sized cerebral arteries (9,10). Haan et al suggested the usefulness of SPECT based on the finding that hypodense lesions observed on CT scans were consistent in part with perfusion defects detected on SPECT (4,11).…”

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confidence: 99%

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Hypoperfusion and Ischemia in Cerebral Amyloid Angiopathy Documented by ^99mTc-ECD Brain Perfusion SPECT

Chung¹,

O²,

Kim³

et al. 2009

J Nucl Med

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Cerebral amyloid angiopathy (CAA) is known to be an important cause of spontaneous cortical-subcortical intracranial hemorrhage in normotensive older persons. CAA can also manifest as leukoencephalopathy, brain atrophy, and ischemia secondary to hypoperfusion. Our goal was to verify cerebral hypoperfusion in patients with CAA using 99m Tc-ethylcysteinate dimer ( 99m Tc-ECD) brain perfusion SPECT. Methods: A total of 11 patients (5 men and 6 women; age range, 58-78 y; mean age 6 SD, 70.0 6 7.0 y) with clinically and radiologically established probable CAA who underwent 99m Tc-ECD SPECT were included. 99m Tc-ECD SPECT scans were also obtained from 13 agematched healthy control subjects (7 men and 6 women; age range, 60-79 y; mean age 6 SD, 66.7 6 6.4 y) for comparison. The relative regional cerebral blood flow values obtained for patients and controls were compared using software. Results: Compared with controls, patients with probable CAA showed hypoperfusion in the inferior parietal lobule of both parietal lobes (Brodmann area [BA] 40), middle temporal gyrus of the left temporal lobe (BA 39), postcentral gyrus of the right parietal lobe, superior temporal gyrus of the right temporal lobe (BA 22), superior temporal gyrus of the right frontal lobe (BA 10), inferior temporal gyrus of the left temporal lobe (BA 20), and both caudate bodies (P , 0.0001, t 5 4.65). Conclusion: Patients with probable CAA had significantly decreased cerebral perfusion and may be at risk for leukoencephalopathy, atrophy, and ischemia.

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%