Heterologous osteosarcomatous and rhabdomyosarcomatous elements in dedifferentiated solitary fibrous tumor: further support for the concept of dedifferentiation in solitary fibrous tumor

Thway, Khin; Hayes, Andrew; Ieremia, Eleni; Fisher, Cyril

doi:10.1016/j.anndiagpath.2012.08.006

Cited by 50 publications

(57 citation statements)

References 42 publications

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“…However, in other reports,2,3 Ewing-like undifferentiated small round cell sarcomas were seen more frequently. In several cases, rhabdomyosarcomatous2 or osteosarcomatous4 features were seen in the dedifferentiated areas. As in our case, the dedifferentiated area is usually negative for CD34,2,3 in contrast to the area of typical SFT, which is positive for CD34.…”

Section: Discussionmentioning

confidence: 99%

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Dedifferentiated Solitary Fibrous Tumor of Thoracic Cavity

et al. 2014

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Section: Discussionmentioning

confidence: 99%

“…This is a phenomenon similar to that seen in dedifferentiated liposarcoma. Dedifferentiated SFT (DSFT) is rare, with less than 30 cases reported worldwide,2,3,4,5,6 and it has not been previously reported in Korea. Here, we present a case of DSFT.…”

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confidence: 99%

Dedifferentiated Solitary Fibrous Tumor of Thoracic Cavity

et al. 2014

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“…37 Among fibroblastic lesions, reactive nodular fibrous pseudotumour can be a late complication of abdominal surgery, especially in males, and arises in mesentery or on the intestinal surface as solitary or multiple hypocellular nodules comprising spindled or stellate fibroblasts dispersed in a densely collagenous stroma. 38 Solitary fibrous tumour has variable fibrosis with random orientation of short spindle cells, is CD34 positive, can undergo dedifferentiation, 39,40 and many cases harbour NAB2-STAT6 gene fusions. 41,42 Low-grade fibromyxoid sarcoma lacks myofibroblastic nuclear features, has whorled fibromyxoid areas, and cellular myxoid foci, and is immunoreactive for MUC4.…”

Section: Differential Diagnosismentioning

confidence: 99%

Aggressive fibromatosis

Fisher

Thway

2014

Pathology

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Aggressive (deep or desmoid-type) fibromatoses are locally infiltrative collagen-forming tumours with potential for recurrence but not metastasis. They exert their clinical effects primarily in relation to location and have variable biological behaviour. In sporadic cases there are somatic mutations in the β-catenin (CTNNB1) gene on 3p21, resulting in immunohistochemically demonstrable overexpression in nuclei. Fibromatosis in patients with familial adenomatous polyposis (FAP) harbours inactivating germline mutations in the desmoid region of the adenomatous polyposis coli (APC) gene on 5q21-q22. The differential diagnosis includes other myofibroblastic lesions, perineurioma, low grade fibromyxoid sarcoma and, in the abdomen, gastrointestinal stromal tumour and liposarcoma with 'low-grade' dedifferentiation. The primary management is surgical, though some desmoids cease to grow and can be watched. Other therapies have a role in stabilising growth or shrinking tumours. Although no single therapy is effective in all cases, available modalities including irradiation, hormonal therapy, chemotherapy, and receptor tyrosine kinase inhibition can be of value in appropriate clinicopathological subgroups.

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“…9 Immunohistochemistry is a significant contributor in distinguishing SFT from other soft-tissue tumours in the head and neck region. SFT strongly stain for CD34 and vimentin.…”

Section: Discussionmentioning

confidence: 99%

MRI findings of solitary fibrous tumours in the head and neck region

Liu¹,

Tao²,

Shi³

et al. 2014

Dentomaxillofacial Radiology

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Objectives: To analyse the MRI findings of solitary fibrous tumours in the head and neck region. Methods: We retrospectively reviewed MR images in eight patients with solitary fibrous tumours proven on histological examination. All the patients underwent conventional MRI, and four patients also underwent dynamic contrast-enhanced MRI and diffusion-weighted imaging in five cases. Image characteristics were analysed. Results: All lesions were found as solitary well-defined masses ranging in size from 1.9 to 6.8 cm (mean, 4.1 cm). They were mostly homogeneous and isointense to the muscle on T 1 weighted images and heterogeneous and mildly hyperintense on T 2 weighted images. After gadolinium administration, areas that were mildly hyperintense on T 2 weighted images were strongly enhanced. They were mildly hyperintense on diffusion-weighted imaging. The average tumour-apparent diffusion coefficient values were 0.001 157 ± 0.000 304 9 mm s 22 compared with the muscle 0.000 760 ± 0.000 265 0 mm s 22 , and there was a statistical difference of p 5 0.002. The time-intensity curves exhibited a rapidly enhancing and a slow washout pattern on dynamic contrast-enhanced MRI. Conclusions: Solitary fibrous tumours should be considered in cases of heterogeneous hypervascular tumours in the head and neck region. Areas of mild hyperintense intensity on T 2 weighted images that are strongly enhanced after gadolinium injection are suggestive of this diagnosis. Non-restricted diffusion and rapidly enhancing and slow washout pattern time-intensity curves may be additional valuable features.

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Heterologous osteosarcomatous and rhabdomyosarcomatous elements in dedifferentiated solitary fibrous tumor: further support for the concept of dedifferentiation in solitary fibrous tumor

Cited by 50 publications

References 42 publications

Dedifferentiated Solitary Fibrous Tumor of Thoracic Cavity

Dedifferentiated Solitary Fibrous Tumor of Thoracic Cavity

Aggressive fibromatosis

MRI findings of solitary fibrous tumours in the head and neck region

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