Heterologous Transplantation of Human and Other Mammalian Tumors

Greene, Harry S. N.

doi:10.1126/science.88.2285.357

Cited by 65 publications

(19 citation statements)

References 3 publications

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“…The implantations were done by forcibly injecting 1 cc., containing 5 to 10 suspended tumor fragments, into the anterior and posterior thigh muscles, muscles of the upper forelegs, and sometimes into the testes, through skin slits made to exclude the carrying of epidermis in on the needle. Individual fragments of certain tumors were implanted in the anterior chamber of the eye according to the method used by Greene (9).…”

mentioning

confidence: 99%

Cancers Deriving From the Virus Papillomas of Wild Rabbits Under Natural Conditions

Kidd

Rous

1940

Journal of Experimental Medicine

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The naturally occurring virus papillomas of western cottontail rabbits become malignant occasionally. The cancers derive from the papilloma cells, that is to say from elements already rendered neoplastic by the virus and still infected therewith. Papillomas produced with the virus in jack rabbits and snowshoe rabbits become cancerous in the same way but much more frequently, as is the case in domestic rabbits also. To all three species the virus is foreign. The character of the cancers of the wild rabbits is described and the relation of the virus to them discussed on the basis of experimental findings. The facts support the view that the cancers result from virus variation, this in many instances being but slight.

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mentioning

confidence: 99%

Cancers Deriving From the Virus Papillomas of Wild Rabbits Under Natural Conditions

Kidd

Rous

1940

Journal of Experimental Medicine

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“…Greene and Lund identified that the heterologous transfer of tissue depended on the developmental stage of the tumor. Ultimately, this meant that tumors containing evidence of infiltration and metastasis in the original host had a higher transplant success rate (3). Additionally, Towbin revealed that the receptivity of the host tissue was a significant factor in the success of xenotransplantation (4).…”

Section: Xenograftsmentioning

confidence: 99%

“…The aim was to differentiate benign growth from malignant growth as the histopathological diagnosis was equivocal in selected cases. The main problem was that tumor growth was not often reproducible and tumor uptake was low (3,4). Greene and Lund identified that the heterologous transfer of tissue depended on the developmental stage of the tumor.…”

Section: Xenograftsmentioning

confidence: 99%

Animal models of extracranial pediatric solid tumors

et al. 2012

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Abstract. Animal models, including xenografts, models of metastatic invasion, syngeneic models and transgenic models, are important tools for basic research in solid pediatric tumors, while humanized animal models are useful for novel immunotherapeutical approaches. Optical and molecular imaging techniques are used for in vivo imaging and may be used in conjunction with alternative treatment approaches, including photodynamic therapy. The aim of this review is to highlight the various animal models that may be used for basic research in pediatric solid tumors.

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“…In those tumours that grew, he described a pinkish colouration of the tumour substance two weeks after transplantation, which represented neovascularisation. If tumour growth was delayed, he observed a lack of vascularisation [19]. Greene moved to Yale University in 1943 and became the Anthony N. Brady Professor and Chairman of the Department of Pathology in 1950.…”

Section: The Beginnings Of Angiogenesis: From Hunter To Folkman-a Slomentioning

confidence: 99%

Tumour Angiogenesis: A Growth Area—From John Hunter to Judah Folkman and Beyond

Stephenson

Goddard

Al-Taan

et al. 2013

Journal of Cancer Research

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Angiogenesis is the growth of new blood vessels in the body. Abnormal angiogenesis is recognised as a “common denominator” in many disease processes, and the development of angiogenesis inhibitors holds great hope in the ongoing battle against cancer. The field of angiogenesis has roots in the Hunterian era of the late eighteenth century but did not begin to blossom until the early 1970s when the then controversial findings and conclusions of Judah Folkman, the “father of angiogenesis,” were first published. There were only 65 publications with angiogenesis in the title in the 10 years after Folkman first proposed the idea of tumour angiogenesis, compared to over 9,000 publications from the year 2000 to 2010. In this review we will explore the voyage of discovery from the first observations of John Hunter in the eighteenth century, via the struggle faced by Folkman to prove the importance of angiogenesis, and finally how his determination has led to modern angiogenesis inhibitors being used in everyday clinical practice.

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Heterologous Transplantation of Human and Other Mammalian Tumors

Cited by 65 publications

References 3 publications

Cancers Deriving From the Virus Papillomas of Wild Rabbits Under Natural Conditions

Cancers Deriving From the Virus Papillomas of Wild Rabbits Under Natural Conditions

Animal models of extracranial pediatric solid tumors

Tumour Angiogenesis: A Growth Area—From John Hunter to Judah Folkman and Beyond

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