2001
DOI: 10.1002/1096-8628(2000)9999:999<00::aid-ajmg1139>3.0.co;2-z
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Heterotaxia as an outcome of maternal diabetes: An epidemiological study

Abstract: There are very few publications on the possible relationship between maternal diabetes and infants presenting heterotaxia-asymmetry defects. In mice, there is a relationship between maternal diabetes and heterotaxia, although this is influenced by the fetal genotype. An epidemiological analysis of heterotaxia-asymmetry in children born to diabetic mothers (diabetes mellitus or gestational diabetes) is presented here. The analysis is based in the case-control study of the ECEMC database. However, due to the ver… Show more

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Cited by 28 publications
(11 citation statements)
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References 18 publications
(26 reference statements)
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“…One of the heterotaxia patients encountered at Yale prior to the time frame under study had this unusual association. More recently, Martinez-Frias demonstrated a strong predilection for offspring of diabetic mothers to present with TGA and visceral heterotaxia [54]. More recently, Martinez-Frias demonstrated a strong predilection for offspring of diabetic mothers to present with TGA and visceral heterotaxia [54].…”
Section: Discussionmentioning
confidence: 97%
“…One of the heterotaxia patients encountered at Yale prior to the time frame under study had this unusual association. More recently, Martinez-Frias demonstrated a strong predilection for offspring of diabetic mothers to present with TGA and visceral heterotaxia [54]. More recently, Martinez-Frias demonstrated a strong predilection for offspring of diabetic mothers to present with TGA and visceral heterotaxia [54].…”
Section: Discussionmentioning
confidence: 97%
“…51 Abnormalities in the determination of left-right (L/R) 55 and human L/R asymmetry malformations. 56 Although retrospective clinical analysis is bound to have limitations in establishing the possible existence of teratogenic factors, since the early 1990s we have been assiduous in detailing this part of the maternal history. The relationship of BASM and maternal diabetes appears to be important.…”
Section: Discussionmentioning
confidence: 99%
“…The more severe laterality defects may include situs ambiguous, complex congenital heart defects (CHD), and spleen anomalies (asplenia, polysplenia) [reviewed by Van Praagh, ; Chin, ]. The cause of most cases of laterality defects remains unknown, although chromosome abnormalities [reviewed by Iida et al, ], other genetic causes [Zhu et al, ; Fakhro et al, ; Cohen, ], and maternal environmental influences [Martínez‐Frías, ] are being increasingly identified as potential causes. Most cases of laterality defects do not have a monogenic etiology [Ferencz et al, ; Lin et al, ; Aylsworth, ], with a few notable exceptions, including X‐linked heterotaxy [Gebbia et al, ; reviewed in Zhu et al, ], autosomal dominant heterotaxy [Alonso et al, ], and Kartagener syndrome (a form of autosomal recessive primary ciliary dyskinesia [PCD]) [Kennedy et al, ; Brueckner, ].…”
Section: Introductionmentioning
confidence: 99%