Heterotope Ossifikationen bei Schwerbrandverletzten

Siemers, Frank; Pl, Stollwerck; Ja, Lohmeyer; Namdar, Thomas; Mailänder, P.

doi:10.1007/s00104-009-1850-5

Cited by 2 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ectopic bone formation is most often experimentally induced, but does also have clinical relevance. For example, ectopic bone has long been described as a congenital or inherited malformation [1][2][3][4], or a complication of various conditions such as paraplegia [5,6], posthip arthroplasty [7,8], postburn, or traumatic injury [9][10][11]. Such pathologic formation of endochondral bone in soft tissues such as muscle, subcutaneous tissue, and fibrous tissue adjacent to joints is called heterotopic ossification (HO).…”

Section: What Is Ectopic Bone Formation?mentioning

confidence: 99%

Brief Review of Models of Ectopic Bone Formation

Scott

Levi

Askarinam

et al. 2012

Stem Cells and Development

183

150

View full text Add to dashboard Cite

Ectopic bone formation is a unique biologic entity--distinct from other areas of skeletal biology. Animal research models of ectopic bone formation most often employ rodent models and have unique advantages over orthotopic (bone) environments, including a relative lack of bone cytokine stimulation and cell-to-cell interaction with endogenous (host) bone-forming cells. This allows for relatively controlled in vivo experimental bone formation. A wide variety of ectopic locations have been used for experimentation, including subcutaneous, intramuscular, and kidney capsule transplantation. The method, benefits and detractions of each method are summarized in the following review. Briefly, subcutaneous implantation is the simplest method. However, the most pertinent concern is the relative paucity of bone formation in comparison to other models. Intramuscular implantation is also widely used and relatively simple, however intramuscular implants are exposed to skeletal muscle satellite progenitor cells. Thus, distinguishing host from donor osteogenesis becomes challenging without cell-tracking studies. The kidney capsule (perirenal or renal capsule) method is less widely used and more technically challenging. It allows for supraphysiologic blood and nutrient resource, promoting robust bone growth. In summary, ectopic bone models are extremely useful in the evaluation of bone-forming stem cells, new osteoinductive biomaterials, and growth factors; an appropriate choice of model, however, will greatly increase experimental success.

show abstract

Section: What Is Ectopic Bone Formation?mentioning

confidence: 99%

Brief Review of Models of Ectopic Bone Formation

Scott

Levi

Askarinam

et al. 2012

Stem Cells and Development

183

150

View full text Add to dashboard Cite

show abstract

Corrective and Reconstructive Surgery in Patients With Postburn Heterotopic Ossification and Bony Ankylosis

Pontell

Sparber

Chamberlain

2015

Journal of Burn Care & Research

View full text Add to dashboard Cite

Articular heterotopic ossification (HO) and subsequent bony ankylosis (BA) are infrequent yet devastating complications of severe burn injuries. These conditions are diagnosed clinically and confirmed by imaging. Patients then begin active physical therapy until cleared for surgery, which remains the standard of care. This study critically reviews the existing literature on the diagnosis, treatment, and surgical outcomes of HO/BA in severely burned patients and provides an evidence-based treatment algorithm. A comprehensive search for all the studies addressing HO and BA after burn injury was conducted using PubMed and Google Scholar from 1957 to 2013. Fifty-one studies on postburn HO/BA have been published, reporting incidences from 0.1 to 35.3%. Most patients suffered from third-degree, thermal burns, with a mean TBSA of 49 ± 14%. The mean time from burn until diagnosis was 7 ± 11 months. Seventy-nine percent of the affected joints were elbows and 84% had adjacent and/or overlying burns. Ninety-one percent of joints had solely extra-articular HO. Ninety percent of HO/BA cases were treated with anatomic excision, and all achieved appreciable increases in range of motion with infrequent recurrence. Perioperative radiotherapy was used infrequently. Surgical articular reconstruction is the standard of care for postburn HO/BA severe enough to limit joint movement and/or function. Early detection and initiation of physical therapy are paramount in preventing progression to complete BA. Increased awareness and more rapid means of detecting postburn articular changes may permit earlier discontinuation of passive range of motion exercises, thereby halting the initiation and progression of HO.

show abstract

Heterotope Ossifikationen bei Schwerbrandverletzten

Cited by 2 publications

References 35 publications

Brief Review of Models of Ectopic Bone Formation

Brief Review of Models of Ectopic Bone Formation

Corrective and Reconstructive Surgery in Patients With Postburn Heterotopic Ossification and Bony Ankylosis

Contact Info

Product

Resources

About