Heterotopic atypical trophoblasts mimicking ectopic choriocarcinoma coexistent with a viable intrauterine pregnancy: A diagnostic dilemma

Mazina, Varvara; Morse, Christopher B.; Hadi, Rouba; Gray, Heidi J.

doi:10.1016/j.gore.2019.03.014

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Choriocarcinoma is a malignant neoplasms that is characterized by high levels of human chorionic gonadotropin (hCG) [ 14 ], Therefore, this neoplasms requires a significant differential diagnosis from pregnancy [ 15 ]. Diagnosis is chiefly characterized by the bleeding of metastatic site [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Ovarian ectopic pregnancy misdiagnosed as gestational choriocarcinoma: A case report

Kazemi

Raoufi

Moghaddam

et al. 2022

Annals of Medicine &Amp; Surgery

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Introduction and importance: Choriocarcinoma is a highly malignant epithelial tumor with often distant metastasis. The clinical presentation of choriocarcinoma depends upon extend of disease and location of metastasis. Case presentation A 35-year-old multiparous woman was presented with severe pelvic pain, fatigue and cough. She was diagnosed with positive pregnancy due to elevated B-hCG and hyperechoic mass in right adnexa. Clinical discussion Exploration surgery showed a larger mass on the right ovary. She was diagnosed with choriocarcinoma however CT scan showed metastasis of lungs, brain and pelvis. She underwent multiple session of chemotherapy, nonetheless, after 8 months, she passed away. Conclusion Timely diagnosis and prompt treatment of choriocarcinoma is necessary to prevent mortality and bad prognosis. It should be differentially diagnosed with all the types of pregnancies.

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Section: Discussionmentioning

confidence: 99%

Ovarian ectopic pregnancy misdiagnosed as gestational choriocarcinoma: A case report

Kazemi

Raoufi

Moghaddam

et al. 2022

Annals of Medicine &Amp; Surgery

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“…In the case of our patient, the vesicular tissue was obvious within the tube. Microscopically diffuse swelling of the villi, diffuse trophoblastic hyperplasia and negative for P57 immuno-histochemical marker are characteristics of CHM (Figure 1A and B) (10). Close followup with weekly hCG titer for 3 normal values (less than 5 mIU/mL) and then monthly for 6 months is essential after surgical removal of the molar tissue.…”

Section: Discussionmentioning

confidence: 99%

A Case of Persistent Intrauterine Molar Pregnancy with Final Diagnosis of Heterotopic Molar Pregnancy: A Very Rare Entity

et al. 2022

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Introduction: Gestational trophoblastic disease (GTD) includes hydatiform mole, choriocarcinoma, placental site trophoblastic tumor, and epithelial trophoblastic tumor. Also, molar pregnancy can happen as an ectopic pregnancy. The coincidence of these complicated pregnancies seems to occur extremely rarely. Case presentation: Here, we presented a 26-year-old woman, nulli gravida with the first presentation of intrauterine complete molar pregnancy; she underwent suction curettage but was prompted to Gestational Trophoblastic Neoplasm (GTN) and she received chemotherapy. During chemotherapy, she had severe abdominal pain and underwent laparotomy, and found an ectopic molar pregnancy in the fallopian tube. Salpingectomy was done and followed up with serum human chorionic gonadotropin (hCG) level and again due to improper decrease of hCG levels, she was diagnosed as a heterotopic post-molar GTN and received methotrexate (MTX) in multiple doses, but she did not respond to MTX, so we started actionomycine-D (Act-D) for her. She was cured after receiving 5 courses of Act-D and now she is on her monthly follow-up with an hCG level. Conclusions: It is important to notice the likelihood of ectopic molar pregnancy or a heterotopic molar pregnancy in the case of managing molar pregnancy, especially when we encounter a case’s poor response to medical or surgical therapy.

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Gestational Choriocarcinoma Misdiagnosed as Ovarian Ectopic Pregnancy

Myneni

2023

The Misdiagnosis Casebook in Clinical Medicine

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Heterotopic atypical trophoblasts mimicking ectopic choriocarcinoma coexistent with a viable intrauterine pregnancy: A diagnostic dilemma

Cited by 4 publications

References 6 publications

Ovarian ectopic pregnancy misdiagnosed as gestational choriocarcinoma: A case report

Ovarian ectopic pregnancy misdiagnosed as gestational choriocarcinoma: A case report

A Case of Persistent Intrauterine Molar Pregnancy with Final Diagnosis of Heterotopic Molar Pregnancy: A Very Rare Entity

Gestational Choriocarcinoma Misdiagnosed as Ovarian Ectopic Pregnancy

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