Heterotopic Gastric Mucosa in the Distal Part of Esophagus in a Teenager

Lupu, Vasile Valeriu; Ignat, Ancuța; Paduraru, Gabriela; Mihăilă, Doina; Burlea, Marin; Ciubară, Anamaria

doi:10.1097/md.0000000000001722

Cited by 26 publications

(27 citation statements)

References 24 publications

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“…Despite this, BPV still fail, especially in a mitral position (30% degeneration at 12-15 years), mainly due to degradation and calcification. Stabilization of tissues by glutaraldehyde promotes cell death, and it has been shown that its activity persists for many months after implantation, slowly releasing active glutaraldehyde monomers that destroy fibrocytes and macrophages that come into contact with the toxic material [10][11][12][13][14][15][16].…”

Section: Resultsmentioning

confidence: 99%

Relationship Between Calcium-phosphorous Product, Native and Bioprosthetic Mitral Valve Calcifications

Enache¹,

Chistol²,

Furnica³

et al. 2017

Rev. Chim.

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Calcification is a common cause of failure of natural and bioprosthetic valves (BPV). Prior research on patients with chronic kidney disease identified increased calcium-phosphorus (Ca-P) product as a risk factor for both arterial and valvular calcifications, an aspect not thoroughly investigated in general population. The aims of our study were to analyse the functional impact of native and bioprosthetic mitral valve (MV) calcification detected on cardiac computed tomography angiography (CCTA), to evaluate risk factors and to assess potential differences from a morphological and chemical point of view between BPV and native MV calcification. The authors performed a retrospective study on 270 patients who underwent CCTA for suspected coronary artery disease, 225 patients with no history of MV replacement and 45 patients with bioprosthetic MV. Mitral leaflet calcification (MLC) was registered in 21 (9.33%) and mitral annular calcification (MAC) in 27 (12%) of the 225 patients suspected for CVD. Echocardiography identified MV sclerosis in 20 cases (8.89%) and MV stenosis in 12 cases (5.33%) with MLC and/or MAC. In the BPV group, 13 patients (28.89%) presented visible BPV calcification associated to echocardiographic regurgitation in 3 (30.77%) cases and higher mean transvalvular gradients. Increased Ca-P product and diabetes mellitus proved to be risk factors for both native and BPV calcification and time since surgery only for BPV calcification. Native and BPV calcification are associated to valve dysfunction and share structural characteristics, thus indicating similar calcification mechanisms. Good glycaemic control in diabetic patients and careful administration of bisphosphonates, calcium and vitamin D supplements are mandatory especially in patients with BPV in order to prevent valve dysfunction due to calcification.

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Section: Resultsmentioning

confidence: 99%

Relationship Between Calcium-phosphorous Product, Native and Bioprosthetic Mitral Valve Calcifications

Enache¹,

Chistol²,

Furnica³

et al. 2017

Rev. Chim.

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“…This type of abnormal tissue can be found in many different areas of the gastrointestinal tract including the rectum, gallbladder, cystic duct, and most commonly in the esophagus. If left unchecked, this type of tissue can lead to gastric ulcers due to high amounts of acid secretion as well as fistulous tracts, strictures, and esophageal webs, and rarely can be a precursor to adenocarcinoma [ 10 , 11 , 12 ]. Data in pediatrics about the incidence and prevalence of this finding are rare, but there have been reports of patients as young as 1 year presenting with this type of tissue found at pathology [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Bleeding Gastric Heterotopic Polyp in the Duodenum of a Teenager with Severe Factor VII Deficiency

Tibesar

2020

Case Rep Gastroenterol

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Heterotopic gastric tissue can be found throughout the intestinal tract, and when it is present in the small intestine, it can present with symptoms that include gastrointestinal bleeding, chronic abdominal pain, diarrhea, and chronic dyspepsia. This finding is incredibly rare in pediatrics, but if present, it can lead to significant morbidity and mortality. This can be especially true if a patient presents with a comorbidity of a bleeding disorder. We here present the case of a teenage male with a history of severe factor VII deficiency who was found to have iron deficiency anemia resulting in multiple blood transfusions from an occult lower gastrointestinal bleed. He was ultimately found to have a bleeding gastric heterotopic polyp in his duodenum that was successfully removed via surgery.

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“…4 Recently, Lupu and colleagues reported the extent of cardiac mucosa and heterotopic gastric mucosa in the distal part of the esophagus in a teenager and pointed out that heterotopic gastric mucosa was mimicking short-segment BE. 31 Considering the congenital component, we reviewed all endoscopic pictures of EGJ in 43 patients aged ≤2 years old. Extent of small tongue-like Z-line without any symptoms of GER was present in a 2-year-old boy (Fig.…”

Section: Is Be a Congenital Or An Acquired Disease?mentioning

confidence: 99%

Endoscopic findings of esophagogastric junction in children

Nakayama

Ida

2017

Digestive Endoscopy

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Esophagogastric landmarks are recognizable in the same way both in children and in adults, and palisade-shaped vessels can be observed at the distal position of esophageal mucosa, even in infants. Few studies have been done in respect to Barrett's esophagus (BE) in children. Incidence of endoscopically suspected BE among all children undergoing esophagogastroduodenoscopy (EGD) is approximately 0.25-1.4%, but can be up to 9.7% in patients with gastroesophageal reflux disease (GERD). Some data suggest that BE is an acquired disorder and point to the possibility of a congenital component in combination with severe mucosal injury. Recent reports noted that multilayered epithelium (ME), which shows morphological and immunocytochemical characteristics of both squamous and columnar epithelium, is associated with goblet cell metaplasia in adult patients with columnar-lined esophagus. The role of ME in the development of intestinal metaplasia in children is uncertain. Furthermore, detailed mechanisms about how short-segment BE (SSBE) changes to long-segment BE (LSBE) are not yet well understood. Further studies are required to understand the pathological esophagogastric junction (EGJ) and BE in children based on reliable epidemiological data and analysis especially in children who have reflux symptoms. Better understanding of the pediatric EGJ and BE may allow improved diagnosis, monitoring, therapy and, therefore, prognosis of GERD-related disorders in adulthood.

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Heterotopic Gastric Mucosa in the Distal Part of Esophagus in a Teenager

Cited by 26 publications

References 24 publications

Relationship Between Calcium-phosphorous Product, Native and Bioprosthetic Mitral Valve Calcifications

Relationship Between Calcium-phosphorous Product, Native and Bioprosthetic Mitral Valve Calcifications

Bleeding Gastric Heterotopic Polyp in the Duodenum of a Teenager with Severe Factor VII Deficiency

Endoscopic findings of esophagogastric junction in children

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