Heterotopic Mesenteric Ossification With Trilineage Hematopoiesis

Abstract

Heterotopic ossification (HO) histologically refers to extraskeletal bone formation in non-ossifying tissues, most commonly noted in the extremities, buttocks, abdominal wall, and hip joints. HO developing in the mesentery (heterotopic mesenteric ossification, HMO) is very rare, with fewer than 100 cases reported in the literature. It usually occurs in adult male patients with a history of repeated abdominal trauma. So far, only two cases of HMO have been reported with the development of hematopoietic bone marrow. Here, we report the third case of HMO with true trilineage hematopoiesis in a 66-year-old female with suspicious mesenteric-retained foreign material from prior surgical procedures, including hysterectomy for endometrial adenocarcinoma and multiple repairs for incisional hernia.

Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification

“…There are limited research studies investigating HSCs’ involvement in HO, and those that are available have provided conflicting evidence of HSC involvement. Several clinical case studies have shown evidence of trilineage hematopoiesis in excised tHO bone [ 131 , 142 , 143 , 144 , 145 ]. Although these case studies indicate the presence and involvement of HSCs in the HO site, there is insufficient evidence to indicate that these cells are involved in the process of osteogenesis in HO formation.…”