Heterotopic Renal Tissue in the Human Adrenal Gland

Milliser, Russell V.; Greenberg, Stephen R.; Neiman, Benjamin H.

doi:10.1016/s0022-5347(17)62127-x

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…Heterotopic kidney tissue (HKT) is a pathologic change occurring when evidence of kidney or kidneylike parenchyma is found within extrarenal organs or tissues in the presence of two functional, otherwise normally located kidneys. 8 HKT has been reported, as an extremely rare and incidental finding, in the human adrenal gland, 5 the human heart, 6 the human lumbosacral region, 1 and the human colon, 4 with the lesion being more frequently encountered in the pelvis rather than the thoracic cavity. 7 To the best of our knowledge, HKT has never been reported, so far, in any domestic or wild animal species.…”

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confidence: 99%

Heterotopic Kidney Tissue in the Lung of a Free-living Common Dolphin (Delphinus delphis)

Guardo¹,

Marruchella²,

Affronte³

et al. 2005

Vet Pathol

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Abstract. A spontaneous case of renal heterotopia involving the lung parenchyma of a free-living, adult, female common dolphin (Delphinus delphis), which was found stranded alive on the North Adriatic Sea coast of Italy, is reported in this study. The lesion, slightly visible from the macroscopic point of view, had the histologic appearance of a ''foreign tissue island,'' which was poorly demarcated from the surrounding pulmonary tissue. Within such an island, several regularly shaped and apparently mature kidney glomeruli and tubules could be observed, with no evidence of secondary tissue reaction. To the best of our knowledge, this should be the first description of heterotopic kidney tissue occurrence in the lung of any domestic or wild animal species.

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confidence: 99%

Heterotopic Kidney Tissue in the Lung of a Free-living Common Dolphin (Delphinus delphis)

Guardo¹,

Marruchella²,

Affronte³

et al. 2005

Vet Pathol

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“…Heterotopic NRs have been reported in several sites including the heart, 19 thorax, 12,16 adrenal gland, 18 colon, 11 and inguinal canal. 4 The few cases of NRs in the lumbosacral area have been associated with spinal dysraphism 1,8,10,24 and, rarer yet, unassociated with spinal abnormalities.…”

mentioning

confidence: 99%

Lumbosacral Ectopic Nephrogenic Rest Unassociated With Spinal Dysraphism

Horenstein

Manci²,

Walker³

et al. 2004

The American Journal of Surgical Pathology

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Nephrogenic rests (NRs) are thought to originate from persistent nephrogenic blastema and are considered precursor lesions of Wilms' tumor (WT). These rests usually occur as perilobar and intralobar lesions in the kidney and, rarely, in ectopic sites. We report a midline lumbosacral ectopic NR in a healthy full-term newborn male with no family history of WT or WT-associated syndromes. The NR presented as a soft polypoid mass covered by normal skin. An MRI study revealed no lumbosacral spine abnormalities and no communication with the vertebral canal. The resected mass measured 3 cm and contained fat and had a central 1.2-cm solid nodule. The nodule was composed of blastema, epithelial elements (mature tubules and nephrons), and abundant stroma. No other somatic tissue elements were identified after complete microscopic examination. There are 4 cases of NRs reported in the lumbosacral area associated with spinal dysraphism, and only 2 cases, in addition to our report, unassociated with spinal abnormalities. The pathogenesis of heterotopic immature nephrogenic tissue remains a source of conjecture and speculation. If these lesions are heterotopic rests, their potential for neoplastic progression is probably quite limited, but if a monodermal teratoma, then more scrupulous clinical follow-up is warranted.

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“…Nephrogenic rests can be subclassified into perilobar nephrogenic rests and intralobar nephrogenic rests, according to their location in relation to the renal lobe on histological examination. Occasionally, nephrogenic rests are found in ectopic sites, such as the inguinal canal [ 5 ], lumbosacral area [ 3 , 9 – 12 ], adrenal gland [ 13 ], thorax [ 14 , 15 ], colon [ 16 ] and heart [ 17 ]. There are two possible distinct fates for nephrogenic rests: to be an isolated developmental abnormality, or the early stage of a neoplastic process, with the latter being more clinically significant.…”

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confidence: 99%

Extrarenal nephroblastomatosis in children: a report of two cases

Zhu

Wang

et al. 2014

BMC Pediatr

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BackgroundExtrarenal nephroblastomatosis is a rare entity which occurs in retroperitoneum and inguinal region predominantly. Here we report two cases of primary extrarenal nephroblastomatosis of Han Chinese in Asian in unusual locations, one is located in testis and paratestis, and the other is paraspinal cord.Case presentationPatient 1 was a 19-month-old boy with a hard and nodular mass adherent to the left testis in inguinal region. Patient 2 was a 9-month-old boy with a 1 × 0.7 × 0.4 cm mass in spinal canal at the midline thoracolumbar region. Histological examinations of the two patients after operations revealed extrarenall nephroblastomatosis with multiple nephrogenic foci, composed of immature glomeruli, tubules and blastemal cells.Then the patients were closely monitored without adjuvant chemotherapy, and has been alive and well without any recurrence for >6 months.ConclusionsMost nephrogenic rests remain subclinical, and thus, complete excision of the lesion with conservative treatment is recommended. Otherwise, nephrogenic rests are close associated with Wilms tumor and regular follow-up is required to ensure early detection of malignant transformation.

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Heterotopic Renal Tissue in the Human Adrenal Gland

Cited by 9 publications

References 13 publications

Heterotopic Kidney Tissue in the Lung of a Free-living Common Dolphin (Delphinus delphis)

Heterotopic Kidney Tissue in the Lung of a Free-living Common Dolphin (Delphinus delphis)

Lumbosacral Ectopic Nephrogenic Rest Unassociated With Spinal Dysraphism

Extrarenal nephroblastomatosis in children: a report of two cases

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