Heterotopic salivary gland adenocarcinoma in the cervical region

Hata, Tomoko; Iga, Hiroki; Imai, Shigeki; Hirokawa, Mitsuyoshi

doi:10.1016/s0901-5027(97)80872-7

Cited by 11 publications

(2 citation statements)

References 6 publications

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“…In addition, we excluded papers for not having HNCUP patient or for using patient data from public databases ( n = 9), for not describing diagnostic or prognostic biomarkers for HNCUP ( n = 4), and finally, for not showing statistically significant data ( n = 4). Finally, the review was performed on a total of 23 studies [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. The flowchart of the systematic search is shown in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

“…A case report described an HNCUP patient with the presence of human salivary alfa-amylase mRNA in an H&N tumor detected by ISH. The primary tumor was most likely a heterotopic salivary gland adenocarcinoma (HSGA); however, it was not found macroscopically in the major salivary glands at autopsy [ 31 ]. Another case report found an HNCUP positive for cytokeratin-7 (CK7) and GATA binding protein 3 (GATA3) and negative for transcriptional thyroid factor 1 (TTF1) and transformation-related protein 63 (p63).…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of Diagnostic and Prognostic Biomarkers for Head and Neck Cancer of Unknown Primary: An Unmet Clinical Need

et al. 2023

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Head and neck cancer of unknown primary (HNCUP) is defined as cervical lymph node metastases without a detectable primary tumor. The management of these patients presents a challenge to clinicians since guidelines in the diagnosis and treatment of HNCUP remain controversial. An accurate diagnostic workup is fundamental for the search for the hidden primary tumor to allow the best adequate treatment strategy. The purpose of this systematic review is to present the currently available data about the diagnostic and prognostic molecular biomarkers for HNCUP. Systematic research in an electronic database was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and identified 704 articles, of which 23 studies were selected and included in the analysis. Fourteen studies investigated HNCUP diagnostic biomarkers and focused on the human papilloma virus (HPV) and the Epstein–Barr virus (EBV) due to the strong associations with oropharyngeal cancer and nasopharyngeal cancer, respectively. HPV status was shown to possess prognostic value, correlating with longer disease-free survival and overall survival. HPV and EBV are the only available HNCUP biomarkers, and they are already used in clinical practice. A better characterization of the molecular profiling and the development of tissue-of-origin classifiers are necessary to improve the diagnosis, staging, and therapeutic management of patients with HNCUP.

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