Heterotopically Induced Osteogenesis in Osteopetrotic Rat Mutants

Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function

“…Another model of osteopetrosis is the incisor absent (ia/ia) rat, characterized by increased bone mass with fair reduction of bone marrow cavities (15). The osteopetrotic(op/op) rat model represents the most severe osteopetrotic phenotype due to the absence of marrow cavities in long bones (16). All types of osteopetrosis resulted from heterogeneous mutations assigned to a single locus on the proximal end of rat chromosome 10 with homology to the proximal end of chromosome 16 in the human genome (17).…”