Heterozygosity for the Alpha‐1‐Antitrypsin Z Allele in Cirrhosis Is Associated With More Advanced Disease

Prince, David; Liu, Ken; McCaughan, Geoffrey W.; Kench, James G.; Strasser, Simone I.

doi:10.1002/lt.25487

Liver Transpl

2019

DOI: 10.1002/lt.25487

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Heterozygosity for the Alpha‐1‐Antitrypsin Z Allele in Cirrhosis Is Associated With More Advanced Disease

David Prince

Ken Liu

Geoffrey W. McCaughan

et al.

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2023

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Alcohol-Associated Liver Disease: Evolving Concepts and Treatments

Prince,

Nash,

Liu

2023

Drugs

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Alcohol is a prominent cause of liver disease worldwide with higher prevalence in developed nations. The spectrum of alcohol-associated liver disease (ALD) encompasses a diverse range of clinical entities, from asymptomatic isolated steatosis to decompensated cirrhosis, and in some cases, acute or chronic liver failure. Consequently, it is important for healthcare practitioners to maintain awareness and systematically screen for ALD. The optimal evaluation and management of ALD necessitates a collaborative approach, incorporating a multidisciplinary team and accounting for concurrent medical conditions. A repertoire of therapeutic interventions exists to support patients in achieving alcohol cessation and sustaining remission, with complete abstinence being the ultimate objective. This review explores the existing therapeutic options for ALD acknowledging geographical discrepancies in accessibility. Recent innovations, including the inclusion of alcohol consumption biomarkers into clinical protocols and the expansion of liver transplantation eligibility to encompass severe alcohol-associated hepatitis, are explored.

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Alcohol-Associated Liver Disease: Evolving Concepts and Treatments

Prince,

Nash,

Liu

2023

Drugs

Self Cite

View full text Add to dashboard Cite

show abstract

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Heterozygosity for the Alpha‐1‐Antitrypsin Z Allele in Cirrhosis Is Associated With More Advanced Disease

Cited by 1 publication

References 3 publications

Alcohol-Associated Liver Disease: Evolving Concepts and Treatments

Alcohol-Associated Liver Disease: Evolving Concepts and Treatments

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