Introduction and purpose: Radiology information system (RIS) in order to reduce workload and improve the quality of services must be well-designed. Heuristic evaluation is one of the methods that understand usability problems with the least time, cost and resources. The aim of present study is to evaluate the usability of RISs in hospitals. Research Method: This is a cross-sectional descriptive study (2015) design and arrangement of software objects cause more attention to these components as principal components in designing UI software. Also, incorrect analysis before system design leads to a lack of attention to secondary needs like Help software and security issues.