2019
DOI: 10.1039/c9ra05352b
|View full text |Cite
|
Sign up to set email alerts
|

Hexachlorobenzene exerts genotoxic effects in a humpback whale cell line under stable exposure conditions

Abstract: Stable exposure concentrations for hexachlorobenzene (HCB) can be achieved using silicone O-rings for passive dosing. Using this setup it was found that HCB causes DNA damage in a cell line of humpback whale fibroblasts.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(3 citation statements)
references
References 56 publications
0
3
0
Order By: Relevance
“…In addition to changes to mitochondrial texture at the two above stated concentrations, fragmented nuclei were visible in the images from p,p’ -DDE exposure (at 20 to 315 nM) (Image SI- section 4). DDE is categorized as a 2B probable human carcinogen and genetic damage may lead to micronucleus formation. , As such these observations may indicate genotoxic action, and further in vitro investigation via, e.g., comet assay is advocated.…”
Section: Resultsmentioning
confidence: 99%
“…In addition to changes to mitochondrial texture at the two above stated concentrations, fragmented nuclei were visible in the images from p,p’ -DDE exposure (at 20 to 315 nM) (Image SI- section 4). DDE is categorized as a 2B probable human carcinogen and genetic damage may lead to micronucleus formation. , As such these observations may indicate genotoxic action, and further in vitro investigation via, e.g., comet assay is advocated.…”
Section: Resultsmentioning
confidence: 99%
“…In snow petrels, circulating levels of legacy POPs were positively correlated with levels of the stress hormone corticosterone (Tartu et al, 2015). Similarly, a humpback whale fibroblast cell line has been applied for the in situ investigation of toxicological effect of HCB and p,p'-DDE via immunotoxic, genotoxic and cell integrity endpoints (Burkard et al, 2015(Burkard et al, , 2019Maner et al, 2019). Further investment into in vitro approaches is suggested for advancing our understanding of the toxicological sensitivity of Antarctic predators.…”
Section: Persistent Organic Pollutantsmentioning
confidence: 99%
“…HCB can also irritate the eyes and the respiratory tract and cause skin lesions, photosensitivity, neuroinflammation, and increased porphyrin excretion [ 2 ]. As a result of the health hazards of HCB, it is classified as a substance possibly carcinogenic to humans (group 2 B) [ 11 , 12 ].…”
Section: Introductionmentioning
confidence: 99%