Hexachlorobenzene (HCB) suppresses circulating progesterone concentrations during the luteal phase in the cynomolgus monkey

Foster, Warren G.; McMahon, Avril; Villeneuve, D. C.; Jarrell, John

doi:10.1002/jat.2550120105

Cited by 31 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, hexachlorobenzene (HCB) has been shown to suppress luteal progesterone synthesis in cynomolgus monkeys (43). We and other investigators (9) have not found that HCB binds to ER (Table 1), which would categorize it as a potential endocrine disruptor but not xenoestrogen.…”

Section: Discussionmentioning

confidence: 82%

Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture.

Zava

Blen

Duwe

1997

Environ Health Perspect

View full text Add to dashboard Cite

We investigated the estrogenic activity of various environmental pollutants (xenobiotics), in particular the xenoestrogen o,p-DDT, and compared their effects with those of endogenous estrogens, phytoestrogens, and mycoestrogens on estrogen receptor binding capacity, induction of estrogen end products, and activation of cell proliferation in estrogen-sensitive human breast cancer cells in monolayer culture. We also quantified the levels of phytoestrogens in extracts of some common foods, herbs, and spices and in human saliva following consumption of a high phytoestrogen food source (soy milk) to compare phytoestrogen abundance and bioavailability relative to the reported xenoestrogen burden in humans. Results show that natural endogenous estrogens, phytoestrogens, mycoestrogens, and xenoestrogens bind estrogen receptor (ER) in intact cells, but demonstrate marked differences in their ability to induce end products of estrogen action and to regulate cell proliferation. All of the different classes of estrogens stimulated cell proliferation at concentrations that half-saturated ER, but only some classes were able to induce estrogen-regulated end products. Genistein, a common phytoestrogen found in soy foods, differed from the xenoestrogen DDT in its effects on cell proliferation and ability to induce estrogen-regulated end products. Moreover, we found that many of the foods, herbs, and spices commonly consumed by humans contain significant amounts of phytoestrogens, and consumption of soy milk, a phytoestrogen-rich food, markedly increases the levels of phytoestrogens in saliva. In conclusion, our in vitro results predict that a diet high in phytoestrogens would significantly reduce the binding of weak xenoestrogens to ER in target tissues in vivo. Environ Health Perspect 1 05(Suppl 3): 637-645 (1997)

show abstract

Section: Discussionmentioning

confidence: 82%

Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture.

Zava

Blen

Duwe

1997

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…However, a nonhuman primate study demonstrated that HCB exposure induced a dose-dependent suppression of luteal serum progesterone (Foster et al 1992). Suppressed luteal progesterone may increase the likelihood of implantation failure due to reduced endometrial maturation or of early pregnancy loss from inadequately low levels of progesterone production (Jones and Wentz 1976).…”

Section: Discussionmentioning

confidence: 99%

Association of Hexachlorobenzene (HCB), Dichlorodiphenyltrichloroethane (DDT), and Dichlorodiphenyldichloroethylene (DDE) with in Vitro Fertilization (IVF) Outcomes

Mahalingaiah

Missmer

Maity

et al. 2012

Environ Health Perspect

View full text Add to dashboard Cite

Background: Hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE) are persistent chlorinated pesticides with endocrine activity that may adversely affect the early stages of human reproduction.Objective: Our goal was to determine the association of serum levels of HCB, DDT, and DDE with implantation failure, chemical pregnancy, and spontaneous abortion in women undergoing in vitro fertilization (IVF) from 1994 to 2003.Methods: Levels of HCB and congeners of DDT and DDE were measured in serum collected during the follicular phase. Multivariable-adjusted statistical models accommodating multiple outcomes and multiple cycles per woman were used to estimate the relation between serum pesticide levels and IVF outcomes.Results: A total of 720 women with a mean ± SD age 35.4 ± 4.2 years at enrollment contributed 774 IVF cycles. All samples had detectable levels of HCB, DDT, and DDE, with median levels of 0.087 ng/g serum for HCB, 1.12 ng/g serum for total DDT, and 1.04 ng/g serum for p,p´-DDE. Compared with the lowest quartile (Q1) of HCB, the lipid- and multivariable-adjusted odds ratio (OR) for failed implantation was significantly elevated for those with higher HCB quartiles [Q2–Q4; adjusted ORs: for Q2, 1.71; 95% confidence interval (CI): 1.03, 2.82; for Q3, 2.30; 95% CI: 1.39, 3.81; for Q4, 2.32; 95% CI: 1.38, 3.90] and showed a significantly increasing trend (p = 0.001). No statistically significant associations were observed between DDT/DDE and IVF outcomes or between HCB and chemical pregnancy or spontaneous abortion.Conclusions: Serum HCB concentrations were on average lower than that of the general U.S. population and associated with failed implantation among women undergoing IVF.

show abstract

“…It has been reported to induce hepatic and thyroid neoplasm,2 3 porphyria,4 5 and hormonal disruption, including alterations in progesterone and testosterone concentrations,6 7 depletion of triiodothyronine (T3) and thyroxine (T4),8goitre,9 and hypothyroidism 10. Very little information on effects on liver function is available, although effects on hepatic γ-glutamyl transpeptidase have been described in rats 11…”

mentioning

confidence: 99%

Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population

Sala¹

2001

Occup Environ Med

View full text Add to dashboard Cite

Objectives-Hexachlorobenzene (HCB) is a highly lipophilic organochlorine compound of widespread environmental occurrence, that accumulates in the biological system. It aVects the porphyrine metabolism, thyroid hormones, and the liver function in animals. Although HCB is one of the most common organochlorine compound in humans, little investigation on its health eVects has been done. Polychlorobiphenyls (PCBs) are also widespread toxic environmental contaminants. The aim of the present study was to investigate the association of serum HCB and PCB concentrations with thyroid hormone status and liver enzymes in human. Methods-Thyroid stimulating hormone (TSH), total and free thyroxine (T4), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and -glutamyltransferase (GGT) were measured as biological markers of thyroid and liver function in a rural population sample older than 14 years (n=192, except for TSH with n=608) highly exposed to HCB. Serum concentrations of HCB were measured by gas chromatography coupled to electron capture detection. Results-After adjustment for confounding variables, there was a significant negative association between serum HCB concentrations and total T4 (a decrease of 0.32 µg/dl per each unit, ln ng/ml, of increase of HCB) and a positive association with GGT (a relative increase of 10 % per each ln unit of increase of HCB), although most subjects (92%) were within the normal range for both T4 and GGT. These associations were not modified after adjustment for total lipid content or for other organochlorine compounds. The association of T4 and GGT with PCB was smaller although significant. No association was found with the other biochemical markers. Conclusions-These results suggest that the internal dose of HCB of this population may reflect a subtle metabolic eVect on thyroid function and an enzymatic induction activity. Further studies are needed to evaluate the health impact of these eVects in more susceptible populations, such as infants. (Occup Environ Med 2001;58:172-177)

show abstract

Hexachlorobenzene (HCB) suppresses circulating progesterone concentrations during the luteal phase in the cynomolgus monkey

Cited by 31 publications

References 20 publications

Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture.

Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture.

Association of Hexachlorobenzene (HCB), Dichlorodiphenyltrichloroethane (DDT), and Dichlorodiphenyldichloroethylene (DDE) with in Vitro Fertilization (IVF) Outcomes

Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population

Contact Info

Product

Resources

About