Hexagonal Boron Nitride/PCL/PLG Coatings on Borate Bioactive Glass Scaffolds for Bone Regeneration

Ensoylu, Mertcan; Deliormanlı, Aylin M.; Atmaca, Harika

doi:10.1007/s10904-022-02246-8

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…This may be attributed to the increase obtained from the in vitro degradation of the glass scaffolds as the hBN concentration increased. Recently, it was seen that when they are used as a coating material inside a polymeric matrix over borate-based 13-93B3 bioactive glass scaffolds, hBN nanoparticles did not show any toxic effect for the same type of cells [ 25 ]. However, in the current study, hBN nanoparticles were embedded directly inside the glass matrix, and following the degradation of the glass in the cell culture medium, 2D nanoparticles may diffuse into the cell membrane more easily.…”

Section: Resultsmentioning

confidence: 99%

“…The polymer foam replication method, which was developed within the scope of another study, was used to manufacture three-dimensional bioactive glass scaffolds that mimic the cancellous bone [ 10 , 25 ]. In the method, poly(urethane) foams with a pore density of 60 pores per inch were cut to a diameter of 12 mm and a length of 35 mm and coated by dipping method using a homogeneously prepared bioactive glass-based suspension (40 vol.% bioactive glass powder, ethanol, 4% ethyl cellulose).…”

Section: Experimental Studiesmentioning

confidence: 99%

“…For this reason, many composite structures, including boron nitride and, especially, hydroxyapatite–boron nitride composites, have been prepared and demonstrated as a scaffolding material for tissue engineering applications as well as a drug delivery vehicle [ 22 , 23 , 24 ]. In a former study, the influence of hexagonal boron nitride nanoparticles incorporated into a PCL and PCL-PLGA matrix, which was coated on the surface of borate bioactive glass scaffolds, have been investigated [ 25 ]. Results showed that the incorporation of hBN nanoparticles inside the polymer matrix improved the compressive strength of the bioactive glass composite scaffolds as well as their in vitro bioactivity and biocompatibility [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…In a former study, the influence of hexagonal boron nitride nanoparticles incorporated into a PCL and PCL-PLGA matrix, which was coated on the surface of borate bioactive glass scaffolds, have been investigated [ 25 ]. Results showed that the incorporation of hBN nanoparticles inside the polymer matrix improved the compressive strength of the bioactive glass composite scaffolds as well as their in vitro bioactivity and biocompatibility [ 25 ]. The function of boron nitride nanosheets as the reinforcing material on the mechanical strength of borosilicate glass matrix was also investigated by Saggar et al [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

2022

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In this study, biomimetic borate-based bioactive glass scaffolds containing hexagonal boron nitride hBN nanoparticles (0.1, 0.2, 0.5, 1, and 2% by weight) were manufactured with the polymer foam replication technique to be used in hard tissue engineering and drug delivery applications. To create three-dimensional cylindrical-shaped scaffolds, polyurethane foams were used as templates and covered using a suspension of glass and hBN powder mixture. Then, a heat treatment was applied at 570 °C in an air atmosphere to remove the polymer foam from the structure and to sinter the glass structures. The structural, morphological, and mechanical properties of the fabricated composites were examined in detail. The in vitro bioactivity of the prepared composites was tested in simulated body fluid, and the release behavior of gentamicin sulfate and 5-fluorouracil from glass scaffolds were analyzed separately as a function of time. The cytotoxicity was investigated using osteoblastic MC3T3-E1 cells. The findings indicated that the hBN nanoparticles, up to a certain concentration in the glass matrix, improved the mechanical strength of the glass scaffolds, which mimic the cancellous bone. Additionally, the inclusion of hBN nanoparticles enhanced the in vitro hydroxyapatite-forming ability of bioactive glass composites. The presence of hBN nanoparticles accelerated the drug release rates of the system. It was concluded that bioactive glass/hBN composite scaffolds mimicking native bone tissue could be used for bone tissue repair and regeneration applications.

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Section: Resultsmentioning

confidence: 99%

Section: Experimental Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

2022

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“…BN membranes can be created by exfoliating bulk BN into thin layers or by synthesizing them through chemical vapor deposition (CVD) techniques. These membranes exhibit high water permeability while maintaining excellent selectivity, making them suitable for water desalination and filtration [90][91][92][93][94][95]. Numerous studies have been conducted to date that suggests the BN and its hybrid membrane are effectively used for oil-water separation.…”

Section: Boron Nitride (Bn)mentioning

confidence: 99%

Two-Dimensional Nanomaterial (2D-NMs)-Based Polymeric Composite for Oil–Water Separation: Strategies to Improve Oil–Water Separation

et al. 2023

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Oil leakage and organic solvent industrial accidents harm the ecosystem, especially aquatic and marine life. Oil–water separation is required to combat this issue, which substantially enhances the ecosystem and recovery of oils from water bodies. In this aspect, significant efforts have been made by scientists to develop newer composite materials that efficiently separate oils from water bodies with exceptional recyclability. Membrane filtration is an efficient option for oil–water separation due to its ability to separate oil from water without involving any chemicals. However, relatively less water permeability and a high degree of surface fouling limit their applicability. The advent of two-dimensional nanomaterials (2D-NMs) gives newer insight in developing membranes due to their exceptional characteristics like hydrophobicity/hydrophilicity, selectivity, antifouling ability, flexibility, and stability. Incorporating 2D-NMs within the polymeric membranes makes them exceptional candidates for removing oil from water. Moreover, 2D-NMs offer rapid sorption/desorption rates and boost water transportation. Additionally, 2D-NMs provide roughness that significantly enhances the fouling resistance in the polymeric membrane. This review focuses on properties of 2D-NM-based polymeric membrane and their roles in oil–water separation. We also discussed strategies to improve the oil–water separation efficiency. Finally, we discussed oil–water separation’s outlook and prospects using 2D-NM-based polymeric membranes. This review might provide new insight to the researchers who work on oil–water separation.

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Two‐Dimensional Nanomaterials‐Based Polymer Nanocomposites for Tissue Engineering Applications

Shahmoradi,

Mirshafiei,

Zare

et al. 2024

Two‐Dimensional Nanomaterials‐Based Polymer Nanocomposites

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Hexagonal Boron Nitride/PCL/PLG Coatings on Borate Bioactive Glass Scaffolds for Bone Regeneration

Cited by 8 publications

References 40 publications

Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

Preparation, Characterization, and Drug Delivery of Hexagonal Boron Nitride-Borate Bioactive Glass Biomimetic Scaffolds for Bone Tissue Engineering

Two-Dimensional Nanomaterial (2D-NMs)-Based Polymeric Composite for Oil–Water Separation: Strategies to Improve Oil–Water Separation

Two‐Dimensional Nanomaterials‐Based Polymer Nanocomposites for Tissue Engineering Applications

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