Hexahydropyrrolo-[2,3-b]-indole Containing Alkaloids as a SARS-CoV-2 Inhibitors: An Integrated Multi-Target Based in-silico Approach
Debasish Mandal
Abstract:The discovery of potential drug molecules which can inhibit multiple targets at a single shot is extremely efficient in combating modern diseases. In continuation of this effort, this manuscript represents a multi-targeted based virtual screening approach aimed at identifying the most promising natural alkaloids based on Hexahydropyrrolo-[2,3-b]-indole backbone as a potential inhibitor against SARS-CoV-2. In this pursuit, eight traditional and understudied SARS-CoV-2 viral targets like the main protease (Mpro)… Show more
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