Hexane extract from Spiranthera odoratissima A. St.-hil. leaves: chemical composition and its bioactive potential against Candida pathogenic species, Leishmania amazonensis and Xylella fastidiosa

Souza, Amanda de; Pereira, Paulo Sérgio; Fernandes, Cassia Cristina; Andrade, Géssica; Pires, Regina Helena; Cândido, Ana Carolina Bolela Bovo; Magalhães, Lizandra Guidi; Vieira, Tatiana Manzini; Crotti, Antônio Eduardo Miller; Martins, Carlos Henrique Gomes; Miranda, Mayker Lázaro Dantas

doi:10.1080/14786419.2021.1931188

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…Relative areas consisted of the average of triplicate GC-FID analyses. GC-MS conditions and the identification have been previously reported (Souza et al, 2021). S1) was based on their retention indices on an Rtx-5MS (30 m X 0.25 mm; 0.250 µm) capillary column under the same operating conditions used for GC relative to a homologous series of n-alkanes (C8-C20).…”

Section: Chemical Identification Of Eo-dl and Eo-fl Constituentsmentioning

confidence: 99%

Chemical composition and anti- Xanthomonas citri activities of essential oils from Schinus molle L. fresh and dry leaves and of its major constituent spathulenol

da Silva,

Fernandes,

Gonçalves

et al. 2023

Natural Product Research

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Citrus canker, which is caused by Xanthomonas citri, is a severe disease that affects citrus plants worldwide. This paper aimed to compare, for the first time, the chemical composition and anti-Xanthomonas citri activities of essential oils from Schinus molle fresh and dry leaves (EO-FL and EO-DL, respectively).Anti-X. citri activity of spathulenol, the major constituent of oils, was also evaluated. Activities were screened by the broth microdilution method on 96-well culture plates. Three major constituents were identified in EO-FL and EO-DL by GC-MS and GC-FID: spathulenol, β-caryophyllene and caryophyllene oxide. EO-DL (MIC = 31.25 µg/mL), EO-FL (MIC = 62.5 µg/mL) and spathulenol (MIC = 100 µg/mL) were active against X. citri strains (resistant, tolerant and sensitive to copper). Even though results showed that in vitro potential of EO-FL, EO-DL and spathulenol against X. citri, further in vivo studies are needed to prove their applicability to the biocontrol of citrus canker.

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Section: Chemical Identification Of Eo-dl and Eo-fl Constituentsmentioning

confidence: 99%

Chemical composition and anti- Xanthomonas citri activities of essential oils from Schinus molle L. fresh and dry leaves and of its major constituent spathulenol

da Silva,

Fernandes,

Gonçalves

et al. 2023

Natural Product Research

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“…For example, Barbosa and co-workers considered that natural products with MIC values equal to or below 500 μg/mL are potent inhibitors of microbial activity [64]. On the other hand, Souza and co-workers established that compounds with MIC ≤ 1000 μg/mL display relevant antifungal activity, whereas MIC ≤ 250 μg/mL denotes highly interesting antifungal activity [65]. Based on these criteria, and inspired by the Oliveira and co-workers' review [66], in this study, the antifungal activity will be classified as follows: MIC ≤ 10 µg/mL, 10 < MIC ≤ 100 µg/mL, 100 < MIC ≤ 500 µg/mL, and 500 < MIC ≤ 1000 µg/mL denotes high, good, moderate, and weak activities, whereas MIC > 1000 µg/mL indicate inactivity.…”

Section: Antifungal Activity Of Sm-eo Cc-eo and Their Blendsmentioning

confidence: 99%

Chemical composition, antileishmanial, and antifungal activi-ties of essential oils from Cinnamomum cassia bark, Schinus molle dried leaves and their blends

Silva,

Fernandes,

dos Santos

et al. 2024

Preprint

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This study reports on the chemical composition and antileishmanial and anticandidal activities of essential oils (EOs) distilled from Schinus molle dried leaves (SM-EO), Cinnamomum cassia branch bark (CC-EO) and their blends against promastigote forms of Leishmania (Leishmania) ama-zonensis and nine Candida strains. Major constituents of SM-EO were spathulenol (26.93%), β-caryophyllene (19.90%), and caryophyllene oxide (12.69%), whereas cinnamaldehyde (60.11%), cinnamyl acetate (20.90%) and (E)-cis-2-methoxycinnamic acid (10.37%) were predominant in CC-EO. SM-EO (IC50 = 21.45 µg/mL) and CC-EO (IC50 = 23.27 µg/mL) displayed good activity against L. amazonensis. SM-EO and CC-EO also proved to be good or moderate activity against nine Can-dida strains, with Minimum Inhibitory Concentration (MIC) values ranging from 31.25 to 250 µg/mL. While the three SM-EO and CC-EO blends were not more active than the EOs tested in-dividually, they exhibited remarkably high antileishmanial activity, with IC50 values ranging between 3.12 and 7.04 µg/mL, which is very similar to the IC50 of amphotericin B (positive con-trol). These results show that SM-EO, CC-EO, and their blends may be considered to participate in the formulation of drugs with antileishmanial and antifungal activities.

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“…Relative areas consisted of the average of triplicate GC-FID analyses. GC-MS conditions and the identification have been previously reported (Souza et al, 2021). Identification of volatile components of HE-PP (Table S1) was based on their retention indices on an Rtx-5MS (30 m X 0.25 mm; 0.250 µm) capillary column under the same operating conditions used for GC relative to a homologous series of n-alkanes (C8-C20).…”

Section: Preparation Of Hexane Extract From P Pubescens Seeds (He-pp)mentioning

confidence: 99%

Volatile compounds of hexane extract from Pterodon pubescens Benth seeds and its significant in vitro potential against different bacterial strains

dos Santos,

Fernandes,

Silva

et al. 2023

Natural Product Research

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Pterodon pubescens Benth is a Brazilian medicinal plant (sucupira, in Brazilian Portuguese). This paper aims to determine the volatile composition and antibacterial activities of hexane extract from P. pubescens seeds (HE-PP).Antibacterial activities were screened by the microdilution broth method in 96-well culture plates and MIC values were expressed as µg/mL. HE-PP was active against several oral bacteria with MIC values between 12.5 µg/mL and 50 µg/mL and against three mycobacterial strains (MIC = 125 µg/mL and 500 µg/mL). In addition, HE-PP was active against Xanthomonas citri strain (MIC = 100 µg/mL). The cytotoxic activity of the extract was evaluated in human tumor and non-tumor cell lines. HE-PP showed selective cytotoxicity to cervical adenocarcinoma (HeLa cells -IC50 = 53.47 µg/mL). The major constituents were identified by GC-MS and GC-FID: E-caryophyllene, vouacapane, Egeranylgeraniol and dehydroabietol. Results reinforce the biological potential of HE-PP against a broad spectrum of pathogenic and phytopathogenic bacteria.

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Hexane extract from Spiranthera odoratissima A. St.-hil. leaves: chemical composition and its bioactive potential against Candida pathogenic species, Leishmania amazonensis and Xylella fastidiosa

Cited by 6 publications

References 20 publications

Chemical composition and anti- Xanthomonas citri activities of essential oils from Schinus molle L. fresh and dry leaves and of its major constituent spathulenol

Chemical composition and anti- Xanthomonas citri activities of essential oils from Schinus molle L. fresh and dry leaves and of its major constituent spathulenol

Chemical composition, antileishmanial, and antifungal activi-ties of essential oils from Cinnamomum cassia bark, Schinus molle dried leaves and their blends

Volatile compounds of hexane extract from Pterodon pubescens Benth seeds and its significant in vitro potential against different bacterial strains

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