Hexokinase as a sugar sensor in higher plants.

Jang, Jyan-Chyun; León, Patricia; Zhou, Li; Sheen, Jen

doi:10.1105/tpc.9.1.5

Cited by 684 publications

(211 citation statements)

References 82 publications

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“…1). Arabidopsis thaliana hexokinase1 (AtHXK1) is the best characterized intracellular sugar receptor [23,26,63,77,78]. The AtHXK1 analogs, OsHXK5 and OsHXK6 [79] or OsHXK7 [80], are present in rice, and their roles in sugar signaling and metabolism have been reported.…”

Section: Receiving and Transmitting The Signals Triggered By Sugarsmentioning

confidence: 99%

“…The diverse cellular localization of this enzyme strongly indicates other functions of HXK than its involvement in glycolysis only [82]. Initially, the participation of HXK in sugar perception and signal transduction was studied by introducing phosphorylated (by HXK) and nonphosphorylated sugar analogs and HXK activity inhibitors, and subsequently by making use of AtHXK1 overexpressing transgenic plants also, predominantly Arabidopsis, or plants in which this gene was expressed in an antisense orientation [26,29,36]. The catalytic functions and roles of HXK as an intracellular glucose sensor were successfully distinguished using gin2-1 HXK mutants, and transgenic plants constructed from these mutants [63].…”

Section: Receiving and Transmitting The Signals Triggered By Sugarsmentioning

confidence: 99%

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Regulatory roles of sugars in plant growth and development

Ciereszko

2018

Acta Soc Bot Pol

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In recent years, several studies have focused on the factors and mechanisms that regulate plant growth and development, as well as the functioning of signaling pathways in plant cells, unraveling the involvement of sugars in the processes regulating such growth and development. Saccharides play an important role in the life of plants: they are structural and storage substances, respiratory substrates, and intermediate metabolites of many biochemical processes. Sucrose is the major transport form of assimilates in plants. Sugars can also play an important role in the defense reactions of plants. However, it has been shown that glucose, sucrose, or trehalose-6-phosphate (Tre6P) can regulate a number of growth and metabolic processes, acting independently of the basal functions; they can also act as signaling molecules. Changes in the concentration, qualitative composition, and transport of sugars occur continuously in plant tissues, during the day and night, as well as during subsequent developmental stages. Plants have developed an efficient system of perception and transmission of signals induced by lower or higher sugar availability. Changes in their concentration affect cell division, germination, vegetative growth, flowering, and aging processes, often independently of the metabolic functions. Currently, the mechanisms of growth regulation in plants, dependent on the access to sugars, are being increasingly recognized. The plant growth stimulating system includes hexokinase (as a glucose sensor), trehalose-6-phosphate, and TOR protein kinase; the lack of Tre6P or TOR kinase inhibits the growth of plants and their transition to the generative phase. It is believed that the plant growth inhibition system consists of SnRK1 protein kinases and C/S1 bZIP transcription factors. The signal transduction routes induced by sugars interact with other pathways in plant tissues (for example, hormonal pathways) creating a complex communication and signaling network in plants that precisely controls plant growth and development.

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Section: Receiving and Transmitting The Signals Triggered By Sugarsmentioning

confidence: 99%

Section: Receiving and Transmitting The Signals Triggered By Sugarsmentioning

confidence: 99%

Regulatory roles of sugars in plant growth and development

Ciereszko

2018

Acta Soc Bot Pol

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“…However, PsJN-inoculated plants grown in 1.5% and 3% (m/v) glucose and fructose did not develop more chlorophyll than uninoculated plants, unlike inoculated plants grown in sucrose. The effect of monosaccharides and disaccharides on StHXK1 activity and physiology in PsJN-inoculated plants indicates that sugars provide a variety of functions in plant growth regulation (Sheen 1990;Jang and Sheen 1994;Jang et al 1997;Rook et al 1998;Rolland et al 2002;Moore et al 2003;Wiese et al 2004;Gibson 2005;Teng et al 2005;Towle 2005;Cho et al 2006;Cho and Yoo 2011;Li et al 2011). For example, glucose enhances cell division, and sucrose enhances cell expansion during plant embryogenesis, while sucrose, glucose, and fructose all enhance formation of adventitious roots on the hypocotyls (Gibson 2005).…”

Section: Discussionmentioning

confidence: 96%

“…It is not clear how 2 different sucrose concentrations trigger different plant growth mechanisms in PsJN-inoculated plants. It is possible that plant growth regulations based on different sugar sensing and signalling could explain the shift from shoot elongation to root mass enlargement (Jang et al 1997;León and Sheen 2003;Cho and Yoo 2011).…”

Section: Discussionmentioning

confidence: 99%

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Involvement of hexokinase1 in plant growth promotion as mediated byBurkholderia phytofirmans

Park

Lazarovits²

2014

Can. J. Microbiol.

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Potato plantlets inoculated with strain PsJN of the bacterium Burkholderia phytofirmans exhibit consistent and significant increases in plant growth under in vitro conditions, when compared with uninoculated plants. The greatest influence on the degree and type of growth enhancement that develops has been shown to be mediated by the sugar concentration in the agar media. Bacterial growth promotion has been suggested in other studies to be regulated by the sugar sensor enzyme hexokinase1, the role of which is activation of glucose phosphorylation. In this present study, we examined the co-relationship between root and stem development in potato plants treated with PsJN and the activity of hexokinase1. Plants grown in the presence of 1.5% and 3% sucrose showed increased levels of hexokinase1 activity only in the roots of inoculated plants, suggesting that the increased enzyme levels may be associated with root growth. Analysis for mRNA using reverse transcriptase did not reveal any significant differences in transcription levels of the gene between inoculated and uninoculated plants. When PsJN-inoculated plants were grown in 1.5% and 3% concentrations of glucose and fructose, stem height and mass, leaf number, root mass, and overall biomass increased. No growth promotion occurred when PsJN-inoculated plants were grown in 3% maltose. Subsequently, a hexokinase1 activity assay showed that PsJN-induced growth of potato plants was found to only occur when plants were grown in the presence of sugars that are recognized by the plant hexokinase1. The results suggest that PsJN may enhance sugar uptake in plants by direct or indirect stimulation of hexokinase1 activity in roots and this results in enhanced overall plant growth.

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Comparative phenotypic and transcriptomic analysis of Victoria and flame seedless grape cultivars during berry ripening

et al. 2020

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Grape berry development is a highly coordinated and intricate process. Herein, we analyzed the phenotypic and transcriptomic patterns of Victoria (VT) and Flame Seedless (FS) grape varieties during berry development. Physiological analysis and transcriptomic sequencing were performed at four berry developmental phases. VT berry size was comparatively larger to the FS variety. At maturity, 80 days post-anthesis (DPA), the FS soluble solids were 61.8% higher than VT. Further, 4,889 and 2,802 differentially expressed genes were identified from VT and FS 40 DPA to 80 DPA development stages, respectively. VvSWEET15, VvHXK and MYB44 genes were up-regulated during the post-anthesis period, while bHLH14, linked to glucose metabolism, was gradually down-regulated during berry development. These genes may have significant roles in berry development, ripening and sugar accumulation.

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Hexokinase as a sugar sensor in higher plants.

Abstract: The mechanisms by which higher plants recognize and respond to sugars are largely unknown. Here, we present evidente that the first enzyme in the hexose assimilation pathway, hexokinase (

Cited by 684 publications

References 82 publications

Regulatory roles of sugars in plant growth and development

Regulatory roles of sugars in plant growth and development

Involvement of hexokinase1 in plant growth promotion as mediated byBurkholderia phytofirmans

Comparative phenotypic and transcriptomic analysis of Victoria and flame seedless grape cultivars during berry ripening

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