Heyde’s Syndrome Complicating Management in a Patient With High Bleeding and Thrombotic Risks

Ahmed, Talha; Haque, Reyaz

doi:10.7759/cureus.8280

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Hudzik et al [5] reported an 82-year-old man with a bleeding colon who survived 12 months. Our patient survived longer than those in all previous reports [3,4,[6][7][8][9][10][11][12][13][14][15][16][17][18]. However, our patient developed Heyde's syndrome after cardiac surgery, and we could not perform further cardiac interventions.…”

Section: Discussion/conclusioncontrasting

confidence: 57%

Long Survival after Gastrointestinal Bleeding in a New-Onset Heyde’s Syndrome Patient Treated with Multiple Endoscopic Hemostatic Procedures and Repeated Transfusions after Aortic Valve Replacement

Notoya

Niikura

Yamada

et al. 2021

Case Rep Gastroenterol

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Heyde’s syndrome, which is caused by aortic stenosis and subsequent acquired von Willebrand factor deficiency, is a gastrointestinal bleeding disease. Gastrointestinal bleeding develops in patients with Heyde’s syndrome, which may have a different prognosis from general gastrointestinal bleeding; thus, it is important to understand the clinical course. We report a 76-year-old Japanese female who underwent aortic mechanical valve replacement 1 year ago and presented with recurrent gastrointestinal bleeding in angiodysplasia of the sigmoid colon. Endoscopic interventions achieved hemostasis. However, 6 rebleeding events occurred due to a sigmoid colon ulcer and gastric and jejunal angiodysplasia 7 years after first hemostasis. The patient underwent multiple endoscopic hemostatic procedures (upper, lower, and balloon-assisted endoscopy) and repeated transfusions (total of 394 units of red blood cells). The intensive treatment contributed to the survival time of 10 years. In addition, we performed a literature review of the prognosis of patients with Heyde’s syndrome.

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Section: Discussion/conclusioncontrasting

confidence: 57%

Long Survival after Gastrointestinal Bleeding in a New-Onset Heyde’s Syndrome Patient Treated with Multiple Endoscopic Hemostatic Procedures and Repeated Transfusions after Aortic Valve Replacement

Notoya

Niikura

Yamada

et al. 2021

Case Rep Gastroenterol

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Transcatheter aortic valve implantation for patients with heyde syndrome: A literature review of case reports

Wang

et al. 2023

Heliyon

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Heyde’s syndrome: a systematic review of case reports

Saha

Wien

Fancher

et al. 2022

BMJ Open Gastroenterol

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ObjectiveHeyde’s syndrome (HS), a rare condition characterised by a unique relationship between severe aortic stenosis and angiodysplasia, is often diagnosed late increasing the risk for a prolonged hospital course and mortality in the elderly. The leading hypothesis explaining the aetiology of HS is acquired von Willebrand syndrome (AVWS) but not all studies support this claim. While individual cases of HS have been reported, here we present the first systematic review of case reports and focus on the prevalence of AVWS.DesignA systematic search was conducted through PubMed/MEDLINE, CINAHL-EBSCO, Web of Science and Google Scholar since inception. The resulting articles were screened by two independent reviewers based on inclusion criteria that the article must be a case report/series or a letter to the editor in English describing HS in an adult patient.ResultsSeventy-four articles encompassing 77 cases met the inclusion criteria. The average age was 74.3±9.3 years old with a slight female predominance. The small intestine, especially the jejunum, was the most common location for bleeding origin. Capsule endoscopy and double balloon enteroscopy were superior at identifying bleeding sources than colonoscopy (p=0.0027 and p=0.0095, respectively) and oesophagogastroduodenoscopy (p=0.0006 and p=0.0036, respectively). The mean duration from symptom onset to diagnosis/treatment of HS was 23.8±39 months. Only 27/77 cases provided evidence for AVWS. Surgical and transcutaneous aortic valve replacement (AVR) were superior at preventing rebleeding than non-AVR modalities (p<0.0001).ConclusionFurther research is warranted for a stronger understanding and increased awareness of HS, which may hasten diagnosis and optimal management.

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Heyde’s Syndrome Complicating Management in a Patient With High Bleeding and Thrombotic Risks

Cited by 3 publications

References 13 publications

Long Survival after Gastrointestinal Bleeding in a New-Onset Heyde’s Syndrome Patient Treated with Multiple Endoscopic Hemostatic Procedures and Repeated Transfusions after Aortic Valve Replacement

Long Survival after Gastrointestinal Bleeding in a New-Onset Heyde’s Syndrome Patient Treated with Multiple Endoscopic Hemostatic Procedures and Repeated Transfusions after Aortic Valve Replacement

Transcatheter aortic valve implantation for patients with heyde syndrome: A literature review of case reports

Heyde’s syndrome: a systematic review of case reports

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