Patient safety is the basic value of service to avoid undesirable incidents to patients. Patient safety targets as a strategy to reduce the risk of near misses, undesirable or unexpected events. One of the hospital's obligations is to improve the quality of hospital services, including patient safety. The purpose of this study was to identify patient safety targets in hospitals. The study design used was a literature review using keywords based on a database of research articles, such as Scopus, ScienceDirect, PubMed, Google Scholar, and Garuda from 2012 to 2022. There were 1408 articles with 10 relevant articles for review and analysis. Knowledge, attitudes, competences, awareness, and culture are important to build the application of patient safety so that a good organizational system, nursing care, and teamwork will increase and also quality of service will be improved in hospital.