Hg&lt;sup&gt;2+&lt;/sup&gt;-Trapping Beads: Hg&lt;sup&gt;2+&lt;/sup&gt;-Specific Recognition through Thymine–Hg(II)–Thymine Base Pairing

Kuriyama, Mituhiro; Haruta, Kaichiro; Dairaku, Takenori; Kawamura, Takahiro; Kikkawa, Shoko; Inamoto, Kiyofumi; Tsukamoto, Hirokazu; Kondo, Yoshinori; Torigoe, Hidetaka; Okamoto, Isaku; Ono, Akira; Morita, Eugene Hayato; Tanaka, Yoshiyuki

doi:10.1248/cpb.c13-00918

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…11). The monomer-based ones include thymine-cross-linked polystyrene beads 95 and uracil-crosslinked polystyrene fibres, 96 and DNA-oligomer-based ones include thymidine-rich-DNA-cross-linked polyacrylamide, 97 T-rich-DNAcross-linked microparticles, 98 oligo-T-cross-linked polystyrene beads, 99,100 and T-rich-DNA-cross-linked silica gel. 101 The thymine/uracil-cross-linked polymer has a high density of Hg 2+ -binding ligands (thymine/uracil) on its polymer surface, 95,96 although the affinity of Hg 2+ for each binding site is not so high.…”

Section: Application In Hg 2+ Trappingmentioning

confidence: 99%

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Structures, physicochemical properties, and applications of T–Hg^II–T, C–Ag^I–C, and other metallo-base-pairs

et al. 2015

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Recently, metal-mediated base-pairs (metallo-base-pairs) have been studied extensively with the aim of exploring novel base-pairs; their structures, physicochemical properties, and applications have been studied. This trend has become more evident after the discovery of Hg(II)-mediated thymine-thymine (T-Hg(II)-T) and Ag(I)-mediated cytosine-cytosine (C-Ag(I)-C) base-pairs. In this article, we focus on the basic science and applications of these metallo-base-pairs, which are composed of natural bases.

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Section: Application In Hg 2+ Trappingmentioning

confidence: 99%

“…[95][96][97][98]100,101 More interestingly, the Hg 2+ -trapping efficiency of T-rich-DNA-cross-linked polystyrene beads was higher in the presence of other cations, which is favourable for their use under natural conditions. 100 In addition, the Hg 2+trapping agents could be recycled several times. [95][96][97][98]101…”

Section: Application In Hg 2+ Trappingmentioning

confidence: 99%

Structures, physicochemical properties, and applications of T–Hg^II–T, C–Ag^I–C, and other metallo-base-pairs

et al. 2015

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“…Thymine has also shown to be a highly specific ligand toward Hg II metal ion [9,10]. The discovery of the linear thymine-Hg II -thymine structure, which affords a high stabilization of thymine-thymine pairs in DNA, has led to the designing and development of recent thymine-based sensors [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging

Orts-Arroyo

Ten-Esteve²,

Ginés-Cárdenas³

et al. 2021

IJMS

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The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging.

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“…Thymine has also shown to be a highly specific ligand towards Hg II metal ion [9,10]. The discovery of the linear thymine-Hg II -thymine structure, which affords a high stabilization of thymine-thymine pairs in DNA, has led to the designing and development of recent thymine-based sensors [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

A Gadolinium(III) Complex Based on the Thymine Nucleobase With Properties Suitable for Magnetic Resonance Imaging Applications

Orts-Arroyo¹,

Ten-Esteve²,

Ginés-Cárdenas³

et al. 2021

Preprint

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The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through vis-IR, SEM-EDAX and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast enhanced magnetic resonance imaging.

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Hg<sup>2+</sup>-Trapping Beads: Hg<sup>2+</sup>-Specific Recognition through Thymine–Hg(II)–Thymine Base Pairing

Cited by 8 publications

References 37 publications

Structures, physicochemical properties, and applications of T–Hg^II–T, C–Ag^I–C, and other metallo-base-pairs

Structures, physicochemical properties, and applications of T–Hg^II–T, C–Ag^I–C, and other metallo-base-pairs

A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging

A Gadolinium(III) Complex Based on the Thymine Nucleobase With Properties Suitable for Magnetic Resonance Imaging Applications

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Hg<sup>2+</sup>-Trapping Beads: Hg<sup>2+</sup>-Specific Recognition through Thymine–Hg(II)–Thymine Base Pairing

Cited by 8 publications

References 37 publications

Structures, physicochemical properties, and applications of T–HgII–T, C–AgI–C, and other metallo-base-pairs

Structures, physicochemical properties, and applications of T–HgII–T, C–AgI–C, and other metallo-base-pairs

A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging

A Gadolinium(III) Complex Based on the Thymine Nucleobase With Properties Suitable for Magnetic Resonance Imaging Applications

Contact Info

Product

Resources

About

Structures, physicochemical properties, and applications of T–Hg^II–T, C–Ag^I–C, and other metallo-base-pairs

Structures, physicochemical properties, and applications of T–Hg^II–T, C–Ag^I–C, and other metallo-base-pairs