The capability of an airborne 2-μm integrated path differential absorption (IPDA) lidar for high-accuracy and high-precision active remote sensing of weighted-average column dry-air volume mixing ratio of atmospheric carbon dioxide (XCO2) is demonstrated. A test flight was conducted over the costal oceanic region of the USA to assess instrument performance during severe weather. The IPDA targets CO2 R30 absorption line using high-energy 2-μm laser transmitter. HgCdTe avalanche photodiode detection system is used in the receiver. Updated instrument model included range correction factor to account for platform attitude. Error budget for XCO2 retrieval predicts lower random error for longer sensing column length. Systematic error is dominated by water vapor (H2O) through dry-air number density derivation, followed by H2O interference and ranging related uncertainties. IPDA XCO2 retrieval results in 404.43 ± 1.23 ppm, as compared to 405.49 ± 0.01 ppm from prediction models, using consistent reflectivity and steady elevation oceanic surface target. This translates to 0.26% and 0.30% relative accuracy and precision, respectively. During gradual spiral descend, IPDA results in 404.89 ± 1.19 ppm as compared model of 404.75 ± 0.73 ppm indicating 0.04% and 0.23% relative accuracy, respectively. Challenging cloud targets limited retrieval accuracy and precision to 2.56% and 4.78%, respectively, due to H2O and ranging errors.